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GENE - CHEMICAL INTERACTIONS REPORT

RGD ID: 620979
Species: Rattus norvegicus
RGD Object: Gene
Symbol: Dnmt1
Name: DNA methyltransferase 1
Acc ID: CHEBI:16243
Term: quercetin
Definition: A pentahydroxyflavone having the five hydroxy groups placed at the 3-, 3'-, 4'-, 5- and 7-positions. It is one of the most abundant flavonoids in edible vegetables, fruit and wine.
Chemical ID: MESH:D011794
Note: Use of the qualifier "multiple interactions" designates that the annotated interaction is comprised of a complex set of reactions and/or regulatory events, possibly involving additional chemicals and/or gene products.
Object SymbolQualifierEvidenceWithReferenceSourceNotesOriginal Reference(s)
Dnmt1decreases expressionISODNMT1 (Homo sapiens)6480464CTDQuercetin results in decreased expression of DNMT1 mRNAPMID:20596804
Dnmt1increases activityISODNMT1 (Homo sapiens)6480464CTDQuercetin results in increased activity of DNMT1 proteinPMID:27132804
Dnmt1increases expressionISODNMT1 (Homo sapiens)6480464CTDQuercetin results in increased expression of DNMT1 mRNAPMID:21632981
Dnmt1multiple interactionsISODNMT1 (Homo sapiens)6480464CTD[Quercetin co-treated with COMT protein] results in decreased activity of DNMT1 protein; Curcumin promotes the reaction [Quercetin results in increased activity of DNMT1 protein]; Quercetin promotes the reaction [Curcumin results in increased activity of DNMT1 protein]PMID:16037419 PMID:27132804
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