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GENE - CHEMICAL INTERACTIONS REPORT

RGD ID: 620966
Species: Rattus norvegicus
RGD Object: Gene
Symbol: Map3k1
Name: mitogen-activated protein kinase kinase kinase 1
Acc ID: CHEBI:49976
Term: zinc dichloride
Definition: A compound of zinc and chloride ions in the ratio 1:2. It exists in four crystalline forms, in each of which the Zn(2+) ions are trigonal planar coordinated to four chloride ions.
Chemical ID: MESH:C016837
Note: Use of the qualifier "multiple interactions" designates that the annotated interaction is comprised of a complex set of reactions and/or regulatory events, possibly involving additional chemicals and/or gene products.
Object SymbolQualifierEvidenceWithReferenceSourceNotesOriginal Reference(s)
Map3k1increases activityISOMap3k1 (Mus musculus)6480464CTDzinc chloride results in increased activity of MAP3K1 proteinPMID:11306679
Map3k1multiple interactionsISOMap3k1 (Mus musculus)6480464CTD2-(4-morpholinyl)-8-phenyl-4H-1-benzopyran-4-one inhibits the reaction [zinc chloride results in increased activity of MAP3K1 protein]; PIK3CG protein affects the reaction [zinc chloride results in increased activity of MAP3K1 protein]PMID:11306679
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