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GENE - CHEMICAL INTERACTIONS REPORT

RGD ID: 620949
Species: Rattus norvegicus
RGD Object: Gene
Symbol: Ugt1a6
Name: UDP glucuronosyltransferase family 1 member A6
Acc ID: CHEBI:46195
Term: paracetamol
Definition: A member of the class of phenols that is 4-aminophenol in which one of the hydrogens attached to the amino group has been replaced by an acetyl group.
Chemical ID: MESH:D000082
Note: Use of the qualifier "multiple interactions" designates that the annotated interaction is comprised of a complex set of reactions and/or regulatory events, possibly involving additional chemicals and/or gene products.
Object SymbolQualifierEvidenceWithReferenceSourceNotesOriginal Reference(s)
Ugt1a6affects expressionEXP 6480464CTDAcetaminophen affects the expression of UGT1A6 mRNAPMID:12883083
Ugt1a6decreases expressionEXP 6480464CTDAcetaminophen results in decreased expression of UGT1A6 mRNAPMID:33387578
Ugt1a6affects glucuronidationISOUGT1A6 (Homo sapiens)6480464CTDUGT1A6 gene polymorphism affects the glucuronidation of AcetaminophenPMID:15761113
Ugt1a6decreases activityISOUGT1A6 (Homo sapiens)6480464CTDAcetaminophen results in decreased activity of UGT1A6 proteinPMID:32421801
Ugt1a6decreases activityISOUgt1a6b (Mus musculus)6480464CTDAcetaminophen results in decreased activity of UGT1A6 proteinPMID:16831125
Ugt1a6decreases expressionISOUGT1A6 (Homo sapiens)6480464CTDAcetaminophen results in decreased expression of UGT1A6 mRNAPMID:29067470
Ugt1a6decreases expressionISOUgt1a6b (Mus musculus)6480464CTDAcetaminophen results in decreased expression of UGT1A6 mRNAPMID:26772156
Ugt1a6increases expressionISOUGT1A6 (Homo sapiens)6480464CTDAcetaminophen results in increased expression of UGT1A6 mRNAPMID:33811995
Ugt1a6increases glucuronidationISOUGT1A6 (Homo sapiens)6480464CTDUGT1A6 protein results in increased glucuronidation of AcetaminophenPMID:11186135 PMID:11903872 PMID:15761113 PMID:17898154
Ugt1a6increases glucuronidationISOUgt1a6b (Mus musculus)6480464CTDUGT1A6 protein results in increased glucuronidation of AcetaminophenPMID:11903872
Ugt1a6multiple interactionsISOUGT1A6 (Homo sapiens)6480464CTD[Acetaminophen co-treated with Oxygen deficiency] results in decreased expression of UGT1A6 mRNA; Acetaminophen inhibits the reaction [UGT1A6 protein results in increased glucuronidation of 4-cresol]; Oxygen deficiency inhibits the reaction [Acetaminophen results in increased expression of UGT1A6 mRNA]PMID:32421801 PMID:33811995
Ugt1a6multiple interactionsISOUgt1a6b (Mus musculus)6480464CTD[NFE2L2 protein affects the expression of UGT1A6 mRNA] which affects the susceptibility to Acetaminophen; hyperoside inhibits the reaction [Acetaminophen results in decreased expression of UGT1A6 mRNA]; SOD1 affects the reaction [Acetaminophen results in decreased activity of UGT1A6 protein]PMID:11134556 PMID:16831125 PMID:26772156
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