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GENE - CHEMICAL INTERACTIONS REPORT

RGD ID: 620949
Species: Rattus norvegicus
RGD Object: Gene
Symbol: Ugt1a6
Name: UDP glucuronosyltransferase family 1 member A6
Acc ID: CHEBI:28119
Term: 2,3,7,8-tetrachlorodibenzodioxine
Definition: A polychlorinated dibenzodioxine that has formula C12H4Cl4O2.
Chemical ID: MESH:D013749
Note: Use of the qualifier "multiple interactions" designates that the annotated interaction is comprised of a complex set of reactions and/or regulatory events, possibly involving additional chemicals and/or gene products.
Object SymbolQualifierEvidenceWithReferenceSourceNotesOriginal Reference(s)
Ugt1a6affects expressionEXP 6480464CTDTetrachlorodibenzodioxin affects the expression of UGT1A6 mRNAPMID:22298810
Ugt1a6increases expressionEXP 6480464CTDTetrachlorodibenzodioxin results in increased expression of UGT1A6 mRNAPMID:11836014 PMID:12948865 PMID:16054898 PMID:18178546 PMID:18465118 PMID:19692669 PMID:20558275 PMID:20959002 PMID:21496263 PMID:22659317
Ugt1a6multiple interactionsEXP 6480464CTDAHR protein promotes the reaction [Tetrachlorodibenzodioxin results in increased expression of UGT1A6 mRNA]PMID:12948865
Ugt1a6affects expressionISOUGT1A6 (Homo sapiens)6480464CTDTetrachlorodibenzodioxin affects the expression of UGT1A6 mRNAPMID:22298810
Ugt1a6increases activityISOUGT1A6 (Homo sapiens)6480464CTDTetrachlorodibenzodioxin results in increased activity of UGT1A6 proteinPMID:12948865
Ugt1a6increases expressionISOUGT1A6 (Homo sapiens)6480464CTDTetrachlorodibenzodioxin results in increased expression of UGT1A6 mRNA; Tetrachlorodibenzodioxin results in increased expression of UGT1A6 proteinPMID:10220484 PMID:11368516 PMID:12948865 PMID:15044633 PMID:16155002 PMID:18061397 PMID:20106945 PMID:21496263 PMID:23669205 PMID:33811995
Ugt1a6increases expressionISOUgt1a6b (Mus musculus)6480464CTDTetrachlorodibenzodioxin results in increased expression of UGT1A6 mRNA; Tetrachlorodibenzodioxin results in increased expression of UGT1A6B mRNAPMID:11043581 PMID:15902423 PMID:16120747 PMID:17035482 PMID:17949056 PMID:18163543 PMID:18372398 PMID:19144771 PMID:19474220 PMID:21496263 PMID:21851831 PMID:24713691
Ugt1a6multiple interactionsISOUGT1A6 (Homo sapiens)6480464CTDAHR protein promotes the reaction [Tetrachlorodibenzodioxin results in increased expression of UGT1A6 mRNA]; NR0B2 protein inhibits the reaction [Tetrachlorodibenzodioxin results in increased expression of UGT1A6 mRNA]; Oxygen deficiency inhibits the reaction [Tetrachlorodibenzodioxin results in increased expression of UGT1A6 mRNA]; Tetrachlorodibenzodioxin promotes the reaction [[AHR protein binds to UGT1A6 5' UTR] which results in increased expression of UGT1A6 mRNA]; Tetrachlorodibenzodioxin promotes the reaction [AHR protein binds to UGT1A6 5' UTR]PMID:11368516 PMID:12948865 PMID:33811995
Ugt1a6multiple interactionsISOUgt1a6b (Mus musculus)6480464CTD2,4,5,2',4',5'-hexachlorobiphenyl promotes the reaction [Tetrachlorodibenzodioxin results in increased expression of UGT1A6B mRNA]; [Tetrachlorodibenzodioxin co-treated with Ethinyl Estradiol] results in increased expression of UGT1A6 mRNA; ARNT affects the reaction [Tetrachlorodibenzodioxin results in increased expression of UGT1A6 mRNA]; NFE2L2 protein affects the reaction [Tetrachlorodibenzodioxin results in increased expression of UGT1A6 mRNA]PMID:11043581 PMID:17942748 PMID:19474220 PMID:21851831
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