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GENE - CHEMICAL INTERACTIONS REPORT

RGD ID: 620945
Species: Rattus norvegicus
RGD Object: Gene
Symbol: Casp8
Name: caspase 8
Acc ID: CHEBI:33216
Term: bisphenol A
Definition: A bisphenol that is 4,4'-methanediyldiphenol in which the methylene hydrogens are replaced by two methyl groups.
Chemical ID: MESH:C006780
Note: Use of the qualifier "multiple interactions" designates that the annotated interaction is comprised of a complex set of reactions and/or regulatory events, possibly involving additional chemicals and/or gene products.
Object SymbolQualifierEvidenceWithReferenceSourceNotesOriginal Reference(s)
Casp8decreases expressionEXP 6480464CTDbisphenol A results in decreased expression of CASP8 mRNAPMID:25181051
Casp8increases activityEXP 6480464CTDbisphenol A results in increased activity of CASP8 proteinPMID:25454643
Casp8increases expressionEXP 6480464CTDbisphenol A results in increased expression of CASP8 mRNAPMID:27539358 PMID:30228064
Casp8multiple interactionsEXP 6480464CTD4-nonylphenol affects the reaction [bisphenol A results in increased expression of CASP8 mRNA]; bisphenol A affects the reaction [4-nonylphenol results in increased expression of CASP8 mRNA]; Melatonin inhibits the reaction [bisphenol A results in increased activity of CASP8 protein]PMID:25454643 PMID:30228064
Casp8affects expressionISOCasp8 (Mus musculus)6480464CTDbisphenol A affects the expression of CASP8 mRNAPMID:26049153 PMID:26746108
Casp8decreases expressionISOCASP8 (Homo sapiens)6480464CTDbisphenol A results in decreased expression of CASP8 proteinPMID:21277958
Casp8increases activityISOCASP8 (Homo sapiens)6480464CTDbisphenol A results in increased activity of CASP8 proteinPMID:30036487 PMID:30841469
Casp8increases activityISOCasp8 (Mus musculus)6480464CTDbisphenol A results in increased activity of CASP8 proteinPMID:31387175
Casp8increases expressionISOCASP8 (Homo sapiens)6480464CTDbisphenol A results in increased expression of CASP8 mRNA; bisphenol A results in increased expression of CASP8 proteinPMID:29275510 PMID:30238673 PMID:30841469 PMID:37143426
Casp8increases expressionISOCasp8 (Mus musculus)6480464CTDbisphenol A results in increased expression of CASP8 mRNA; bisphenol A results in increased expression of CASP8 proteinPMID:23900028 PMID:30951980 PMID:31387175
Casp8multiple interactionsISOCasp8 (Mus musculus)6480464CTD[bisphenol A co-treated with Diethylhexyl Phthalate co-treated with Dibutyl Phthalate co-treated with butylbenzyl phthalate co-treated with diethyl phthalate co-treated with di-n-octyl phthalate co-treated with diisodecyl phthalate co-treated with diisononyl phthalate] results in increased expression of CASP8 protein; [bisphenol A co-treated with Diethylhexyl Phthalate co-treated with diethyl phthalate co-treated with diisononyl phthalate co-treated with di-n-octyl phthalate co-treated with Dibutyl Phthalate co-treated with butylbenzyl phthalate co-treated with diisodecyl phthalate] results in increased expression of CASP8 proteinPMID:35739755 PMID:37364641
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