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GENE - CHEMICAL INTERACTIONS REPORT

RGD ID: 620945
Species: Rattus norvegicus
RGD Object: Gene
Symbol: Casp8
Name: caspase 8
Acc ID: CHEBI:15367
Term: all-trans-retinoic acid
Definition: A retinoic acid in which all four exocyclic double bonds have E- (trans-) geometry.
Chemical ID: MESH:D014212
Note: Use of the qualifier "multiple interactions" designates that the annotated interaction is comprised of a complex set of reactions and/or regulatory events, possibly involving additional chemicals and/or gene products.
Object SymbolQualifierEvidenceWithReferenceSourceNotesOriginal Reference(s)
Casp8increases cleavageISOCASP8 (Homo sapiens)6480464CTDTretinoin results in increased cleavage of CASP8 proteinPMID:16135400
Casp8increases expressionISOCASP8 (Homo sapiens)6480464CTDTretinoin results in increased expression of CASP8 mRNAPMID:33167477
Casp8multiple interactionsISOCASP8 (Homo sapiens)6480464CTD[Tretinoin co-treated with Paclitaxel] results in increased cleavage of CASP8 protein; TGFB1 protein inhibits the reaction [Tretinoin results in increased cleavage of and results in increased activity of CASP8 protein]; Tretinoin results in increased cleavage of and results in increased activity of CASP8 proteinPMID:16242776 PMID:18098270
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