GENE - CHEMICAL INTERACTIONS REPORT
Note: Use of the qualifier "multiple interactions" designates that the annotated interaction
is comprised of a complex set of reactions and/or regulatory events, possibly involving
additional chemicals and/or gene products.
Object Symbol | Qualifier | Evidence | With | Reference | Source | Notes | Original Reference(s) | Casp7 | increases cleavage | ISO | CASP7 (Homo sapiens) | 6480464 | CTD | Methotrexate results in increased cleavage of CASP7 protein | PMID:18483502 PMID:24967384 | Casp7 | increases expression | ISO | CASP7 (Homo sapiens) | 6480464 | CTD | Methotrexate results in increased expression of CASP7 mRNA | PMID:21678067 | Casp7 | multiple interactions | ISO | CASP7 (Homo sapiens) | 6480464 | CTD | [Methotrexate co-treated with CDKN1A protein] results in increased cleavage of CASP7 protein; [Methotrexate co-treated with CDKN1A protein] results in increased expression of CASP7 mRNA; ESRRA protein inhibits the reaction [Methotrexate results in increased cleavage of CASP7 protein] | PMID:18483502 PMID:24967384 | | ||||||||||||||||||||||
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