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GENE - TERM ANNOTATION REPORT

RGD ID: 620937
Species: Rattus norvegicus
RGD Object: Gene
Symbol: Mlh1
Name: mutL homolog 1
Acc ID: GO:0008630
Term: intrinsic apoptotic signaling pathway in response to DNA damage
Definition: The series of molecular signals in which an intracellular signal is conveyed to trigger the apoptotic death of a cell. The pathway is induced by the detection of DNA damage, and ends when the execution phase of apoptosis is triggered.
Definition Source(s): GOC:go_curators, GOC:mtg_apoptosis
Note: Use of the qualifier "multiple interactions" designates that the annotated interaction is comprised of a complex set of reactions and/or regulatory events, possibly involving additional chemicals and/or gene products.
Object SymbolQualifierEvidenceWithReferenceSourceNotesOriginal Reference(s)
Mlh1acts_upstream_of_or_withinISOMlh1 (Mus musculus)1624291RGDMGI:1857946 PMID:14562041

PMID:14562041
Mlh1involved_inIEAUniProtKB:Q9JK91 or ensembl:ENSMUSP000000350791600115EnsemblGO_REF:0000107

GO_REF:0000107
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