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GENE - CHEMICAL INTERACTIONS REPORT

RGD ID: 620925
Species: Rattus norvegicus
RGD Object: Gene
Symbol: Ppargc1a
Name: PPARG coactivator 1 alpha
Acc ID: CHEBI:81584
Term: 2,2',4,4'-Tetrabromodiphenyl ether
Definition: An organobromine compound that has formula C12H6Br4O.
Chemical ID: MESH:C511295
Note: Use of the qualifier "multiple interactions" designates that the annotated interaction is comprised of a complex set of reactions and/or regulatory events, possibly involving additional chemicals and/or gene products.
Object SymbolQualifierEvidenceWithReferenceSourceNotesOriginal Reference(s)
Ppargc1adecreases expressionEXP 6480464CTD2,2',4,4'-tetrabromodiphenyl ether results in decreased expression of PPARGC1A mRNA; 2,2',4,4'-tetrabromodiphenyl ether results in decreased expression of PPARGC1A proteinPMID:36269211
Ppargc1amultiple interactionsEXP 6480464CTDMIR128-1 promotes the reaction [2,2',4,4'-tetrabromodiphenyl ether results in decreased expression of PPARGC1A mRNA]; MIR128-1 promotes the reaction [2,2',4,4'-tetrabromodiphenyl ether results in decreased expression of PPARGC1A protein]; ZLN005 inhibits the reaction [2,2',4,4'-tetrabromodiphenyl ether results in decreased expression of PPARGC1A mRNA]; ZLN005 inhibits the reaction [2,2',4,4'-tetrabromodiphenyl ether results in decreased expression of PPARGC1A protein]PMID:36269211
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