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GENE - CHEMICAL INTERACTIONS REPORT

RGD ID: 620925
Species: Rattus norvegicus
RGD Object: Gene
Symbol: Ppargc1a
Name: PPARG coactivator 1 alpha
Acc ID: CHEBI:29699
Term: tunicamycin
Definition: A mixture of antiviral nucleoside antibiotics produced by Streptomyces lysosuperificus. It contains at least 10 homologues comprising uracil, N-acetylglucosamine, an 11-carbon aminodialdose called tunicamine, and a fatty acid linked to the amino group of the tunicamine. The homologues vary in the composition of the fatty acid moiety.
Chemical ID: MESH:D014415
Note: Use of the qualifier "multiple interactions" designates that the annotated interaction is comprised of a complex set of reactions and/or regulatory events, possibly involving additional chemicals and/or gene products.
Object SymbolQualifierEvidenceWithReferenceSourceNotesOriginal Reference(s)
Ppargc1adecreases expressionISOPpargc1a (Mus musculus)6480464CTDTunicamycin results in decreased expression of PPARGC1A mRNA; Tunicamycin results in decreased expression of PPARGC1A proteinPMID:28482072
Ppargc1aincreases expressionISOPpargc1a (Mus musculus)6480464CTDTunicamycin results in increased expression of PPARGC1A mRNAPMID:22414386
Ppargc1amultiple interactionsISOPpargc1a (Mus musculus)6480464CTDCEBPB protein inhibits the reaction [Tunicamycin results in decreased expression of PPARGC1A protein]PMID:28482072
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