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GENE - CHEMICAL INTERACTIONS REPORT

RGD ID: 620925
Species: Rattus norvegicus
RGD Object: Gene
Symbol: Ppargc1a
Name: PPARG coactivator 1 alpha
Acc ID: CHEBI:16412
Term: lipopolysaccharide
Definition: Liposaccharide natural compounds consisting of a trisaccharide repeating unit (two heptose units and octulosonic acid) with oligosaccharide side chains and 3-hydroxytetradecanoic acid units (they are a major constituent of the cell walls of Gram-negative bacteria).
Chemical ID: MESH:D008070
Note: Use of the qualifier "multiple interactions" designates that the annotated interaction is comprised of a complex set of reactions and/or regulatory events, possibly involving additional chemicals and/or gene products.
Object SymbolQualifierEvidenceWithReferenceSourceNotesOriginal Reference(s)
Ppargc1adecreases expressionEXP 6480464CTDLipopolysaccharides results in decreased expression of PPARGC1A proteinPMID:22610192
Ppargc1aincreases expressionEXP 6480464CTDLipopolysaccharides results in increased expression of PPARGC1A proteinPMID:19853624
Ppargc1amultiple interactionsEXP 6480464CTD[Aminoimidazole Carboxamide analog co-treated with Lipopolysaccharides] results in increased expression of PPARGC1A protein; [Lipopolysaccharides co-treated with Tobacco Smoke Pollution] results in decreased expression of PPARGC1A mRNA; [Lipopolysaccharides co-treated with Tobacco Smoke Pollution] results in decreased expression of PPARGC1A protein; Aminoimidazole Carboxamide analog promotes the reaction [Lipopolysaccharides results in increased expression of PPARGC1A protein]; Curcumin inhibits the reaction [[Lipopolysaccharides co-treated with Tobacco Smoke Pollution] results in decreased expression of PPARGC1A mRNA]; Curcumin inhibits the reaction [[Lipopolysaccharides co-treated with Tobacco Smoke Pollution] results in decreased expression of PPARGC1A protein]; dorsomorphin inhibits the reaction [Aminoimidazole Carboxamide analog promotes the reaction [Lipopolysaccharides results in increased expression of PPARGC1A protein]]; Resveratrol inhibits the reaction [Lipopolysaccharides results in decreased expression of PPARGC1A protein]PMID:19853624 PMID:22610192 PMID:28951138
Ppargc1adecreases expressionISOPpargc1a (Mus musculus)6480464CTDLipopolysaccharides results in decreased expression of PPARGC1A mRNAPMID:16847310 PMID:21873422 PMID:22240665
Ppargc1adecreases expressionISOPPARGC1A (Homo sapiens)6480464CTDLipopolysaccharides results in decreased expression of PPARGC1A mRNAPMID:35811015
Ppargc1amultiple interactionsISOPpargc1a (Mus musculus)6480464CTD[Ethylene Chlorohydrin co-treated with Lipopolysaccharides] results in increased expression of PPARGC1A mRNA; pyrazolanthrone inhibits the reaction [Lipopolysaccharides results in decreased expression of PPARGC1A mRNA]; Sirolimus inhibits the reaction [[Ethylene Chlorohydrin co-treated with Lipopolysaccharides] results in increased expression of PPARGC1A mRNA]PMID:21873422 PMID:31499194
Ppargc1amultiple interactionsISOPPARGC1A (Homo sapiens)6480464CTDS-(1,2-dichlorovinyl)cysteine inhibits the reaction [Lipopolysaccharides results in decreased expression of PPARGC1A mRNA]PMID:35811015
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