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GENE - TERM ANNOTATION REPORT

RGD ID: 620918
Species: Rattus norvegicus
RGD Object: Gene
Symbol: Rab27a
Name: RAB27A, member RAS oncogene family
Acc ID: GO:0006887
Term: exocytosis
Definition: A process of secretion by a cell that results in the release of intracellular molecules (e.g. hormones, matrix proteins) contained within a membrane-bounded vesicle. Exocytosis can occur either by full fusion, when the vesicle collapses into the plasma membrane, or by a kiss-and-run mechanism that involves the formation of a transient contact, a pore, between a granule (for exemple of chromaffin cells) and the plasma membrane. The latter process most of the time leads to only partial secretion of the granule content. Exocytosis begins with steps that prepare vesicles for fusion with the membrane (tethering and docking) and ends when molecules are secreted from the cell.
Definition Source(s): GOC:mah, ISBN:0716731363, PMID:22323285
Note: Use of the qualifier "multiple interactions" designates that the annotated interaction is comprised of a complex set of reactions and/or regulatory events, possibly involving additional chemicals and/or gene products.
Object SymbolQualifierEvidenceWithReferenceSourceNotesOriginal Reference(s)
Rab27ainvolved_inISORAB27A (Homo sapiens)1624291RGD PMID:18812475

PMID:18812475
Rab27a TAS 1601610RGD  
Rab27ainvolved_inIBAFB:FBgn0025382 or MGI:1861441 or PANTHER:PTN001178482 or UniProtKB:P51159 or WB:WBGene000000891600115GO_CentralGO_REF:0000033

GO_REF:0000033
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