A member of the class of rotenones that consists of 1,2,12,12a-tetrahydrochromeno[3,4-b]furo[2,3-h]chromen-6(6aH)-one substituted at position 2 by a prop-1-en-2-yl group and at positions 8 and 9 by methoxy groups (the 2R,6aS,12aS-isomer). A non-systemic insecticide, it is the principal insecticidal constituent of derris (the dried rhizome and root of Derris elliptica).
Chemical ID:
MESH:D012402
Note: Use of the qualifier "multiple interactions" designates that the annotated interaction
is comprised of a complex set of reactions and/or regulatory events, possibly involving
additional chemicals and/or gene products.
[Particulate Matter co-treated with Rotenone] results in decreased expression of PRKN protein; [Rotenone co-treated with Luteolin] results in increased expression of PRKN mRNA; Indomethacin promotes the reaction [PRKN gene mutant form results in increased susceptibility to Rotenone]; Luteolin inhibits the reaction [Rotenone results in decreased expression of PRKN mRNA]; Minocycline inhibits the reaction [PRKN gene mutant form results in increased susceptibility to Rotenone]; Sirolimus inhibits the reaction [[Particulate Matter co-treated with Rotenone] results in decreased expression of PRKN protein]
[Particulate Matter co-treated with Rotenone] results in decreased expression of PRKN protein; Chloroquine inhibits the reaction [Venlafaxine Hydrochloride inhibits the reaction [Rotenone results in decreased expression of PRKN protein]]; Sirolimus inhibits the reaction [[Particulate Matter co-treated with Rotenone] results in decreased expression of PRKN protein]; Venlafaxine Hydrochloride inhibits the reaction [Rotenone results in decreased expression of PRKN protein]
4,5,6,7-tetrabromobenzotriazole inhibits the reaction [Rotenone results in increased expression of PRKN protein]; CSNK2A1 protein affects the reaction [Rotenone results in increased expression of PRKN protein]; DNM1L protein affects the reaction [Rotenone affects the localization of PRKN protein]; PGAM5 protein affects the reaction [Rotenone results in increased expression of PRKN protein]; PRKN protein inhibits the reaction [LRRK2 gene polymorphism results in increased susceptibility to Rotenone]; Rotenone promotes the reaction [PRKN protein binds to PINK1 protein]; Rotenone results in increased phosphorylation of and affects the localization of PRKN protein
