GENE - CHEMICAL INTERACTIONS REPORT
Note: Use of the qualifier "multiple interactions" designates that the annotated interaction
is comprised of a complex set of reactions and/or regulatory events, possibly involving
additional chemicals and/or gene products.
Object Symbol | Qualifier | Evidence | With | Reference | Source | Notes | Original Reference(s) | Txnip | increases activity | EXP | | 6480464 | CTD | Glucose results in increased activity of TXNIP mRNA | PMID:21832250 | Txnip | increases expression | EXP | | 6480464 | CTD | Glucose results in increased expression of TXNIP protein | PMID:17178593 PMID:23647015 PMID:29031534 | Txnip | increases response to substance | EXP | | 6480464 | CTD | TXNIP mRNA results in increased susceptibility to Glucose | PMID:23647015 | Txnip | multiple interactions | EXP | | 6480464 | CTD | Allopurinol inhibits the reaction [Glucose results in increased expression of TXNIP protein]; Quercetin inhibits the reaction [Glucose results in increased expression of TXNIP protein]; rhodioloside inhibits the reaction [Glucose results in increased expression of TXNIP protein]; TXNIP mRNA promotes the reaction [Glucose results in decreased expression of PPARA protein]; TXNIP mRNA promotes the reaction [Glucose results in increased expression of CASP1 protein]; TXNIP mRNA promotes the reaction [Glucose results in increased expression of TXNIP protein]; TXNIP protein affects the reaction [Glucose results in increased expression of CERT1 mRNA]; TXNIP protein affects the reaction [Glucose results in increased expression of FN1 mRNA]; TXNIP protein affects the reaction [Glucose results in increased expression of FN1 protein] | PMID:23647015 PMID:29031534 | Txnip | decreases expression | ISO | TXNIP (Homo sapiens) | 6480464 | CTD | Glucose deficiency results in decreased expression of TXNIP mRNA; Glucose deficiency results in decreased expression of TXNIP protein | PMID:20195491 | Txnip | increases expression | ISO | TXNIP (Homo sapiens) | 6480464 | CTD | Glucose results in increased expression of TXNIP protein | PMID:23647015 | Txnip | increases expression | ISO | Txnip (Mus musculus) | 6480464 | CTD | Glucose results in increased expression of TXNIP mRNA; Glucose results in increased expression of TXNIP protein | PMID:17178593 PMID:22869588 PMID:31974165 | Txnip | increases response to substance | ISO | TXNIP (Homo sapiens) | 6480464 | CTD | TXNIP mRNA results in increased susceptibility to Glucose | PMID:23647015 | Txnip | multiple interactions | ISO | TXNIP (Homo sapiens) | 6480464 | CTD | [Glucose co-treated with TGFB1 protein] results in increased expression of TXNIP protein; Allopurinol inhibits the reaction [Glucose results in increased expression of TXNIP protein]; aucubin inhibits the reaction [[Glucose co-treated with TGFB1 protein] results in increased expression of TXNIP protein]; Quercetin inhibits the reaction [Glucose results in increased expression of TXNIP protein]; TXNIP mRNA promotes the reaction [Glucose results in decreased expression of PPARA protein]; TXNIP mRNA promotes the reaction [Glucose results in increased expression of CASP1 protein]; TXNIP mRNA promotes the reaction [Glucose results in increased expression of TXNIP protein] | PMID:23647015 PMID:35961541 | Txnip | multiple interactions | ISO | Txnip (Mus musculus) | 6480464 | CTD | [[[[Glucose results in decreased expression of MIR17 mRNA] which results in increased expression of TXNIP mRNA] which results in increased expression of TXNIP protein] promotes the reaction [TXNIP protein binds to TXN1 protein]] which results in increased activity of MAP3K5 protein; [Glucose promotes the reaction [TXNIP protein binds to TXN1 protein]] which results in increased activity of MAP3K5 protein; [Glucose results in decreased expression of MIR17 mRNA] which results in increased expression of TXNIP mRNA; [Glucose results in decreased expression of MIR17 mRNA] which results in increased stability of TXNIP protein; [NFE2L2 protein binds to TXNIP promoter] inhibits the reaction [Glucose results in increased expression of TXNIP mRNA]; Glucose promotes the reaction [TXNIP protein binds to TXN1 protein]; Glucose promotes the reaction [TXNIP results in increased abundance of Reactive Oxygen Species]; GPD2 protein inhibits the reaction [Glucose results in increased expression of TXNIP mRNA]; Metformin inhibits the reaction [Glucose results in increased expression of TXNIP mRNA]; NFE2L2 protein inhibits the reaction [Glucose results in increased expression of TXNIP mRNA]; TXNIP promotes the reaction [Glucose results in increased expression of FN1 mRNA]; TXNIP promotes the reaction [Glucose results in increased expression of LAMB1 mRNA]; TXNIP promotes the reaction [Glucose results in increased expression of LAMB2 mRNA]; TXNIP promotes the reaction [Glucose results in increased expression of LAMB3 mRNA]; TXNIP promotes the reaction [Glucose results in increased expression of LAMC1 mRNA] | PMID:17178593 PMID:22869588 PMID:26660634 PMID:31974165 | | ||||||||||||||||||||||
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