GENE - CHEMICAL INTERACTIONS REPORT
Note: Use of the qualifier "multiple interactions" designates that the annotated interaction
is comprised of a complex set of reactions and/or regulatory events, possibly involving
additional chemicals and/or gene products.
Object Symbol | Qualifier | Evidence | With | Reference | Source | Notes | Original Reference(s) | Txnip | increases expression | EXP | | 6480464 | CTD | Thioacetamide results in increased expression of TXNIP mRNA | PMID:34492290 | Txnip | increases response to substance | ISO | Txnip (Mus musculus) | 6480464 | CTD | TXNIP protein results in increased susceptibility to Thioacetamide | PMID:20713078 | Txnip | multiple interactions | ISO | Txnip (Mus musculus) | 6480464 | CTD | [TXNIP gene mutant form co-treated with Thioacetamide] results in increased expression of BCL2 protein; TXNIP gene mutant form inhibits the reaction [Thioacetamide results in increased activity of CASP3 protein]; TXNIP gene mutant form inhibits the reaction [Thioacetamide results in increased activity of CASP9 protein]; TXNIP gene mutant form inhibits the reaction [Thioacetamide results in increased expression of BAX protein]; TXNIP gene mutant form inhibits the reaction [Thioacetamide results in increased phosphorylation of MAPK1 protein]; TXNIP gene mutant form inhibits the reaction [Thioacetamide results in increased phosphorylation of MAPK3 protein] | PMID:20713078 | |
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