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GENE - CHEMICAL INTERACTIONS REPORT

RGD ID: 620857
Species: Rattus norvegicus
RGD Object: Gene
Symbol: Pla2g2a
Name: phospholipase A2 group IIA
Acc ID: CHEBI:50131
Term: 5-aza-2'-deoxycytidine
Definition: A 2'-deoxyribonucleoside that has formula C8H12N4O4.
Chemical ID: MESH:C014347
Note: Use of the qualifier "multiple interactions" designates that the annotated interaction is comprised of a complex set of reactions and/or regulatory events, possibly involving additional chemicals and/or gene products.
Object SymbolQualifierEvidenceWithReferenceSourceNotesOriginal Reference(s)
Pla2g2aaffects expressionISOPLA2G2A (Homo sapiens)6480464CTDDecitabine affects the expression of PLA2G2A mRNAPMID:23300844
Pla2g2adecreases methylationISOPLA2G2A (Homo sapiens)6480464CTDDecitabine results in decreased methylation of PLA2G2A promoterPMID:18953428
Pla2g2aincreases expressionISOPLA2G2A (Homo sapiens)6480464CTDDecitabine results in increased expression of PLA2G2A mRNA; Decitabine results in increased expression of PLA2G2A proteinPMID:18320072 PMID:18953428
Pla2g2amultiple interactionsISOPLA2G2A (Homo sapiens)6480464CTD2-(2-amino-3-methoxyphenyl)-4H-1-benzopyran-4-one promotes the reaction [IFNG protein promotes the reaction [Decitabine results in increased expression of PLA2G2A protein]]; caffeic acid phenethyl ester inhibits the reaction [IFNG protein promotes the reaction [Decitabine results in increased expression of PLA2G2A protein]]; Colforsin inhibits the reaction [IFNG protein promotes the reaction [Decitabine results in increased expression of PLA2G2A protein]]; IFNG protein promotes the reaction [Decitabine results in increased expression of PLA2G2A protein]; Plicamycin inhibits the reaction [IFNG protein promotes the reaction [Decitabine results in increased expression of PLA2G2A protein]]; Tetradecanoylphorbol Acetate inhibits the reaction [IFNG protein promotes the reaction [Decitabine results in increased expression of PLA2G2A protein]]PMID:18953428
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