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GENE - CHEMICAL INTERACTIONS REPORT

RGD ID: 620850
Species: Rattus norvegicus
RGD Object: Gene
Symbol: Nppc
Name: natriuretic peptide C
Acc ID: CHEBI:16469
Term: 17beta-estradiol
Definition: The 17beta-isomer of estradiol.
Chemical ID: MESH:D004958
Note: Use of the qualifier "multiple interactions" designates that the annotated interaction is comprised of a complex set of reactions and/or regulatory events, possibly involving additional chemicals and/or gene products.
Object SymbolQualifierEvidenceWithReferenceSourceNotesOriginal Reference(s)
Nppcincreases expressionISONPPC (Homo sapiens)6480464CTDEstradiol results in increased expression of NPPC mRNAPMID:23019147 PMID:25136773
Nppcincreases expressionISONppc (Mus musculus)6480464CTDEstradiol results in increased expression of NPPC mRNA; Estradiol results in increased expression of NPPC proteinPMID:9435603
Nppcmultiple interactionsISONPPC (Homo sapiens)6480464CTDESR1 mutant form inhibits the reaction [Estradiol results in increased expression of NPPC mRNA]PMID:25136773
Nppcmultiple interactionsISONppc (Mus musculus)6480464CTDDactinomycin inhibits the reaction [Estradiol results in increased expression of NPPC mRNA]; fulvestrant inhibits the reaction [Estradiol results in increased expression of NPPC mRNA]; Progesterone inhibits the reaction [Estradiol results in increased expression of NPPC protein]PMID:9435603
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