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GENE - CHEMICAL INTERACTIONS REPORT

RGD ID: 620824
Species: Rattus norvegicus
RGD Object: Gene
Symbol: Polr1a
Name: RNA polymerase I subunit A
Acc ID: CHEBI:29865
Term: benzo[a]pyrene
Definition: An ortho- and peri-fused polycyclic arene consisting of five fused benzene rings.
Chemical ID: MESH:D001564
Note: Use of the qualifier "multiple interactions" designates that the annotated interaction is comprised of a complex set of reactions and/or regulatory events, possibly involving additional chemicals and/or gene products.
Object SymbolQualifierEvidenceWithReferenceSourceNotesOriginal Reference(s)
Polr1adecreases methylationISOPOLR1A (Homo sapiens)6480464CTDBenzo(a)pyrene results in decreased methylation of POLR1A promoterPMID:27901495
Polr1aincreases expressionISOPolr1a (Mus musculus)6480464CTDBenzo(a)pyrene results in increased expression of POLR1A mRNAPMID:22228805
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