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GENE - CHEMICAL INTERACTIONS REPORT

RGD ID: 620817
Species: Rattus norvegicus
RGD Object: Gene
Symbol: Aifm1
Name: apoptosis inducing factor, mitochondria associated 1
Acc ID: CHEBI:45863
Term: paclitaxel
Definition: A tetracyclic diterpenoid isolated originally from the bark of the Pacific yew tree, Taxus brevifolia. It is a mitotic inhibitor used in cancer chemotherapy. Note that the use of the former generic name 'taxol' is now limited, as Taxol is a registered trade mark.
Chemical ID: MESH:D017239
Note: Use of the qualifier "multiple interactions" designates that the annotated interaction is comprised of a complex set of reactions and/or regulatory events, possibly involving additional chemicals and/or gene products.
Object SymbolQualifierEvidenceWithReferenceSourceNotesOriginal Reference(s)
Aifm1increases expressionISOAIFM1 (Homo sapiens)6480464CTDPaclitaxel results in increased expression of AIFM1 mRNAPMID:18058816
Aifm1multiple interactionsISOAIFM1 (Homo sapiens)6480464CTD[Doxorubicin co-treated with Paclitaxel co-treated with Fluorouracil] results in increased expression of AIFM1 protein; [Doxorubicin co-treated with Paclitaxel] results in increased expression of AIFM1 protein; [Tretinoin co-treated with Paclitaxel] affects the localization of AIFM1 protein; [Tretinoin co-treated with Paclitaxel] results in increased expression of AIFM1 proteinPMID:16168113 PMID:17701358
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