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GENE - CHEMICAL INTERACTIONS REPORT

RGD ID: 620817
Species: Rattus norvegicus
RGD Object: Gene
Symbol: Aifm1
Name: apoptosis inducing factor, mitochondria associated 1
Acc ID: CHEBI:28119
Term: 2,3,7,8-tetrachlorodibenzodioxine
Definition: A polychlorinated dibenzodioxine that has formula C12H4Cl4O2.
Chemical ID: MESH:D013749
Note: Use of the qualifier "multiple interactions" designates that the annotated interaction is comprised of a complex set of reactions and/or regulatory events, possibly involving additional chemicals and/or gene products.
Object SymbolQualifierEvidenceWithReferenceSourceNotesOriginal Reference(s)
Aifm1decreases expressionEXP 6480464CTDTetrachlorodibenzodioxin results in decreased expression of AIFM1 mRNA; Tetrachlorodibenzodioxin results in decreased expression of AIFM1 proteinPMID:16497791 PMID:33387578
Aifm1affects expressionISOAifm1 (Mus musculus)6480464CTDTetrachlorodibenzodioxin affects the expression of AIFM1 mRNAPMID:21570461
Aifm1decreases expressionISOAIFM1 (Homo sapiens)6480464CTDTetrachlorodibenzodioxin results in decreased expression of AIFM1 mRNAPMID:23152189
Aifm1multiple interactionsISOAifm1 (Mus musculus)6480464CTD[Tetrachlorodibenzodioxin co-treated with Ethinyl Estradiol] results in increased expression of AIFM1 mRNA; Tetrachlorodibenzodioxin promotes the reaction [AHR protein binds to AIFM1 promoter]PMID:17942748 PMID:19654925
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