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GENE - CHEMICAL INTERACTIONS REPORT

RGD ID: 620817
Species: Rattus norvegicus
RGD Object: Gene
Symbol: Aifm1
Name: apoptosis inducing factor, mitochondria associated 1
Acc ID: CHEBI:9168
Term: sirolimus
Definition: A macrolide lactam isolated from Streptomyces hygroscopicus consisting of a 29-membered ring containing 4 trans double bonds, three of which are conjugated. It is an antibiotic, immunosupressive and antineoplastic agent.
Chemical ID: MESH:D020123
Note: Use of the qualifier "multiple interactions" designates that the annotated interaction is comprised of a complex set of reactions and/or regulatory events, possibly involving additional chemicals and/or gene products.
Object SymbolQualifierEvidenceWithReferenceSourceNotesOriginal Reference(s)
Aifm1decreases expressionEXP 6480464CTDSirolimus results in decreased expression of AIFM1 proteinPMID:16497721
Aifm1multiple interactionsISOAIFM1 (Homo sapiens)6480464CTD[7-hydroxystaurosporine co-treated with Sirolimus] affects the localization of AIFM1 protein; Boc-D-FMK inhibits the reaction [[Sirolimus co-treated with 7-hydroxystaurosporine] affects the localization of AIFM1 protein]PMID:15767555
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