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GENE - CHEMICAL INTERACTIONS REPORT

RGD ID: 620816
Species: Rattus norvegicus
RGD Object: Gene
Symbol: Pdcd4
Name: programmed cell death 4
Acc ID: CHEBI:15367
Term: all-trans-retinoic acid
Definition: A retinoic acid in which all four exocyclic double bonds have E- (trans-) geometry.
Chemical ID: MESH:D014212
Note: Use of the qualifier "multiple interactions" designates that the annotated interaction is comprised of a complex set of reactions and/or regulatory events, possibly involving additional chemicals and/or gene products.
Object SymbolQualifierEvidenceWithReferenceSourceNotesOriginal Reference(s)
Pdcd4affects localizationISOPDCD4 (Homo sapiens)6480464CTDTretinoin affects the localization of PDCD4 proteinPMID:17259349
Pdcd4increases expressionISOPDCD4 (Homo sapiens)6480464CTDTretinoin results in increased expression of PDCD4 mRNA; Tretinoin results in increased expression of PDCD4 proteinPMID:17259349 PMID:30093655
Pdcd4increases response to substanceISOPDCD4 (Homo sapiens)6480464CTDPDCD4 protein results in increased susceptibility to TretinoinPMID:17259349
Pdcd4multiple interactionsISOPDCD4 (Homo sapiens)6480464CTD2-(4-morpholinyl)-8-phenyl-4H-1-benzopyran-4-one promotes the reaction [Tretinoin results in increased expression of PDCD4 protein]; PDCD4 protein promotes the reaction [Tretinoin results in decreased expression of WT1 protein]; PDCD4 protein promotes the reaction [Tretinoin results in increased expression of EIF4G2 protein]; Sirolimus promotes the reaction [Tretinoin results in increased expression of PDCD4 protein]PMID:17259349
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