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GENE - CHEMICAL INTERACTIONS REPORT

RGD ID: 620809
Species: Rattus norvegicus
RGD Object: Gene
Symbol: Slc12a2
Name: solute carrier family 12 member 2
Acc ID: CHEBI:47426
Term: furosemide
Definition: A chlorobenzoic acid that is 4-chlorobenzoic acid substituted by a (furan-2-ylmethyl)amino and a sulfamoyl group at position 2 and 5 respectively. It is a diuretic used in the treatment of congestive heart failure.
Chemical ID: MESH:D005665
Note: Use of the qualifier "multiple interactions" designates that the annotated interaction is comprised of a complex set of reactions and/or regulatory events, possibly involving additional chemicals and/or gene products.
Object SymbolQualifierEvidenceWithReferenceSourceNotesOriginal Reference(s)
Slc12a2multiple interactionsEXP 6480464CTD[Furosemide results in decreased activity of SLC12A2 protein] affects the reaction [Thioctic Acid inhibits the reaction [Ammonia results in increased secretion of S100B protein]]; [Furosemide results in decreased activity of SLC12A2 protein] inhibits the reaction [Ammonia results in increased secretion of S100B protein]; [Furosemide results in decreased activity of SLC12A2 protein] promotes the reaction [Thioctic Acid results in decreased activity of Ammonia]; [Furosemide results in decreased activity of SLC12A2 protein] which results in decreased susceptibility to Ammonia; [Furosemide results in decreased activity of SLC12A2 protein] which results in increased activity of AmmoniaPMID:23880158
Slc12a2decreases activityISOSLC12A2 (Homo sapiens)6480464CTDFurosemide results in decreased activity of SLC12A2 proteinPMID:29959396
Slc12a2multiple interactionsISOSLC12A2 (Homo sapiens)6480464CTDFurosemide inhibits the reaction [SLC12A2 protein results in increased uptake of Rubidium]PMID:29959396
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