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GENE - CHEMICAL INTERACTIONS REPORT

RGD ID: 620778
Species: Rattus norvegicus
RGD Object: Gene
Symbol: Siah2
Name: siah E3 ubiquitin protein ligase 2
Acc ID: CHEBI:40710
Term: ICI-164384
Definition: A 3-hydroxy steroid that is 17beta-estradiol substituted by a 11-[butyl(methyl)amino]-11-oxoundecyl group at position 7R. It is a steroidal antioestrogen that inhibits the cell proliferation of breast-carcinoma cell lines.
Chemical ID: MESH:C051781
Note: Use of the qualifier "multiple interactions" designates that the annotated interaction is comprised of a complex set of reactions and/or regulatory events, possibly involving additional chemicals and/or gene products.
Object SymbolQualifierEvidenceWithReferenceSourceNotesOriginal Reference(s)
Siah2affects response to substanceISOSIAH2 (Homo sapiens)6480464CTDSIAH2 protein affects the susceptibility to ICI 164384PMID:18629630
Siah2decreases expressionISOSIAH2 (Homo sapiens)6480464CTDICI 164384 results in decreased expression of SIAH2 mRNAPMID:18629630
Siah2multiple interactionsISOSIAH2 (Homo sapiens)6480464CTDICI 164384 inhibits the reaction [[Estradiol co-treated with EGFR protein] results in increased expression of SIAH2 mRNA]PMID:18629630
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