GENE - CHEMICAL INTERACTIONS REPORT
Note: Use of the qualifier "multiple interactions" designates that the annotated interaction
is comprised of a complex set of reactions and/or regulatory events, possibly involving
additional chemicals and/or gene products.
Object Symbol | Qualifier | Evidence | With | Reference | Source | Notes | Original Reference(s) | Ptges | multiple interactions | EXP | | 6480464 | CTD | [Diclofenac results in decreased expression of PTGES mRNA] which results in decreased abundance of Dinoprostone | PMID:19393675 | Ptges | increases abundance | ISO | PTGES (Homo sapiens) | 6480464 | CTD | PTGES results in increased abundance of Dinoprostone | PMID:17369862 | Ptges | multiple interactions | ISO | Ptges (Mus musculus) | 6480464 | CTD | [GPX2 protein affects the expression of PTGES protein] which affects the metabolism of Dinoprostone; [IL6 protein results in increased expression of PTGES mRNA] which results in increased secretion of and results in increased abundance of Dinoprostone; [Lithium Chloride results in increased expression of PTGES protein] which results in increased chemical synthesis of Dinoprostone; [Tetrachlorodibenzodioxin results in increased expression of PTGES mRNA] which results in increased chemical synthesis of Dinoprostone; PTGES protein affects the reaction [Tetrachlorodibenzodioxin results in increased abundance of Dinoprostone] | PMID:18479189 PMID:19692487 PMID:22430074 PMID:24285838 | Ptges | multiple interactions | ISO | PTGES (Homo sapiens) | 6480464 | CTD | [IL1B protein results in increased expression of PTGES protein] which results in increased abundance of Dinoprostone; [Oxygen deficiency results in increased expression of PTGES protein] which results in increased chemical synthesis of Dinoprostone; cobaltiprotoporphyrin inhibits the reaction [[IL1B protein results in increased expression of PTGES protein] which results in increased abundance of Dinoprostone]; HIF1A protein promotes the reaction [[Oxygen deficiency results in increased expression of PTGES protein] which results in increased chemical synthesis of Dinoprostone]; HMOX1 protein promotes the reaction [cobaltiprotoporphyrin inhibits the reaction [[IL1B protein results in increased expression of PTGES protein] which results in increased abundance of Dinoprostone]] | PMID:19428335 PMID:20042640 | | ||||||||||||||||||||||
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