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GENE - CHEMICAL INTERACTIONS REPORT

RGD ID: 62071
Species: Rattus norvegicus
RGD Object: Gene
Symbol: Gap43
Name: growth associated protein 43
Acc ID: CHEBI:81582
Term: 2,4-dibromophenyl 2,4,5-tribromophenyl ether
Definition: A polybromodiphenyl ether that is diphenyl ether in which the hydrogens at the 2, 4, 5, 2', and 4' positions have been replaced by bromines.
Chemical ID: MESH:C477694
Note: Use of the qualifier "multiple interactions" designates that the annotated interaction is comprised of a complex set of reactions and/or regulatory events, possibly involving additional chemicals and/or gene products.
Object SymbolQualifierEvidenceWithReferenceSourceNotesOriginal Reference(s)
Gap43decreases expressionEXP 6480464CTD2,2',4,4',5-brominated diphenyl ether results in decreased expression of GAP43 mRNAPMID:19954255
Gap43increases expressionEXP 6480464CTD2,2',4,4',5-brominated diphenyl ether results in increased expression of GAP43 mRNAPMID:19954255
Gap43multiple interactionsEXP 6480464CTD2,2',4,4',5-brominated diphenyl ether results in increased expression of and results in increased phosphorylation of GAP43 proteinPMID:19954255
Gap43increases expressionISOGAP43 (Homo sapiens)6480464CTD2,2',4,4',5-brominated diphenyl ether results in increased expression of GAP43 mRNAPMID:26705709
Gap43increases expressionISOGap43 (Mus musculus)6480464CTD2,2',4,4',5-brominated diphenyl ether results in increased expression of GAP43 proteinPMID:16451863 PMID:18550172 PMID:21820030
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