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GENE - CHEMICAL INTERACTIONS REPORT

RGD ID: 620683
Species: Rattus norvegicus
RGD Object: Gene
Symbol: Rps6kb1
Name: ribosomal protein S6 kinase B1
Acc ID: CHEBI:6925
Term: microcystin-LR
Definition: A microcystin consisting of D-alanyl, L-leucyl, (3S)-3-methyl-D-beta-aspartyl,L-arginyl, 2S,3S,4E,6E,8S,9S)-3-amino-4,5,6,7-tetradehydro-9-methoxy-2,6,8-trimethyl-10-phenyldecanoyl, D-gamma-glutamyl, and 2,3-didehydro-N-methylalanyl residues joined into a 25-membered macrocycle. Produced by the cyanobacterium Microcystis aeruginosa, it is the most studied of the microcystins.
Chemical ID: MESH:C057862
Note: Use of the qualifier "multiple interactions" designates that the annotated interaction is comprised of a complex set of reactions and/or regulatory events, possibly involving additional chemicals and/or gene products.
Object SymbolQualifierEvidenceWithReferenceSourceNotesOriginal Reference(s)
Rps6kb1increases phosphorylationEXP 6480464CTDcyanoginosin LR results in increased phosphorylation of RPS6KB1 proteinPMID:15342961
Rps6kb1multiple interactionsEXP 6480464CTDnaringin inhibits the reaction [cyanoginosin LR results in increased phosphorylation of RPS6KB1 protein]PMID:15342961
Rps6kb1increases expressionISORPS6KB1 (Homo sapiens)6480464CTDcyanoginosin LR results in increased expression of RPS6KB1 protein modified formPMID:28984034
Rps6kb1increases phosphorylationISORPS6KB1 (Homo sapiens)6480464CTDcyanoginosin LR results in increased phosphorylation of RPS6KB1 proteinPMID:26506538 PMID:34432352
Rps6kb1increases phosphorylationISORps6kb1 (Mus musculus)6480464CTDcyanoginosin LR results in increased phosphorylation of RPS6KB1 proteinPMID:31714646
Rps6kb1multiple interactionsISORPS6KB1 (Homo sapiens)6480464CTD2-(4-morpholinyl)-8-phenyl-4H-1-benzopyran-4-one inhibits the reaction [cyanoginosin LR results in increased phosphorylation of RPS6KB1 protein]; cyanoginosin LR promotes the reaction [INS protein results in increased expression of RPS6KB1 protein modified form]; INS protein promotes the reaction [cyanoginosin LR results in increased expression of RPS6KB1 protein modified form]; Metformin inhibits the reaction [cyanoginosin LR results in increased phosphorylation of RPS6KB1 protein]; Sirolimus inhibits the reaction [cyanoginosin LR promotes the reaction [INS protein results in increased expression of RPS6KB1 protein modified form]]; Sirolimus inhibits the reaction [cyanoginosin LR results in increased expression of RPS6KB1 protein modified form]; Sirolimus inhibits the reaction [cyanoginosin LR results in increased phosphorylation of RPS6KB1 protein]; Sirolimus inhibits the reaction [INS protein promotes the reaction [cyanoginosin LR results in increased expression of RPS6KB1 protein modified form]]PMID:26506538 PMID:28984034 PMID:34432352
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