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GENE - CHEMICAL INTERACTIONS REPORT

RGD ID: 620683
Species: Rattus norvegicus
RGD Object: Gene
Symbol: Rps6kb1
Name: ribosomal protein S6 kinase B1
Acc ID: CHEBI:35456
Term: cadmium dichloride
Definition: A cadmium coordination entity in which cadmium(2+) and Cl(-) ions are present in the ratio 2:1. Although considered to be ionic, it has considerable covalent character to its bonding.
Chemical ID: MESH:D019256
Note: Use of the qualifier "multiple interactions" designates that the annotated interaction is comprised of a complex set of reactions and/or regulatory events, possibly involving additional chemicals and/or gene products.
Object SymbolQualifierEvidenceWithReferenceSourceNotesOriginal Reference(s)
Rps6kb1decreases expressionEXP 6480464CTDCadmium Chloride results in decreased expression of RPS6KB1 mRNAPMID:33453195
Rps6kb1increases expressionEXP 6480464CTDCadmium Chloride results in increased expression of RPS6KB1 mRNAPMID:21297351
Rps6kb1increases phosphorylationEXP 6480464CTDCadmium Chloride results in increased phosphorylation of RPS6KB1 proteinPMID:18021293 PMID:21195169 PMID:21544200 PMID:21933187 PMID:24111524
Rps6kb1multiple interactionsEXP 6480464CTD1,2-bis(2-aminophenoxy)ethane N,N,N',N'-tetraacetic acid acetoxymethyl ester inhibits the reaction [Cadmium Chloride results in increased phosphorylation of RPS6KB1 protein]; Acetylcysteine inhibits the reaction [Cadmium Chloride results in increased phosphorylation of RPS6KB1 protein]; AICA ribonucleotide inhibits the reaction [Cadmium Chloride results in increased phosphorylation of RPS6KB1 protein]; CAMK2A mutant form inhibits the reaction [Cadmium Chloride results in increased phosphorylation of RPS6KB1 protein]; celastrol inhibits the reaction [Cadmium Chloride results in increased phosphorylation of RPS6KB1 protein]; Egtazic Acid inhibits the reaction [Cadmium Chloride results in increased phosphorylation of RPS6KB1 protein]; KN 93 inhibits the reaction [Cadmium Chloride results in increased phosphorylation of RPS6KB1 protein]; PTEN protein inhibits the reaction [Cadmium Chloride results in increased phosphorylation of RPS6KB1 protein]; PTEN protein promotes the reaction [celastrol inhibits the reaction [Cadmium Chloride results in increased phosphorylation of RPS6KB1 protein]]; Sirolimus inhibits the reaction [Cadmium Chloride results in increased phosphorylation of RPS6KB1 protein]; Trifluoperazine inhibits the reaction [Cadmium Chloride results in increased phosphorylation of RPS6KB1 protein]; Wortmannin inhibits the reaction [Cadmium Chloride results in increased phosphorylation of RPS6KB1 protein]PMID:18021293 PMID:21195169 PMID:21544200 PMID:21933187 PMID:24111524
Rps6kb1decreases expressionISORps6kb1 (Mus musculus)6480464CTDCadmium Chloride results in decreased expression of RPS6KB1 mRNAPMID:35843418
Rps6kb1decreases phosphorylationISORps6kb1 (Mus musculus)6480464CTDCadmium Chloride results in decreased phosphorylation of RPS6KB1 proteinPMID:35843418
Rps6kb1increases phosphorylationISORPS6KB1 (Homo sapiens)6480464CTDCadmium Chloride results in increased phosphorylation of RPS6KB1 proteinPMID:18021293 PMID:25118938 PMID:33127495
Rps6kb1increases phosphorylationISORps6kb1 (Mus musculus)6480464CTDCadmium Chloride results in increased phosphorylation of RPS6KB1 proteinPMID:21544200 PMID:24299490
Rps6kb1multiple interactionsISORPS6KB1 (Homo sapiens)6480464CTD2-(4-morpholinyl)-8-phenyl-4H-1-benzopyran-4-one inhibits the reaction [Cadmium Chloride results in increased phosphorylation of and results in increased activity of RPS6KB1 protein]; Cadmium Chloride results in increased phosphorylation of and results in increased activity of RPS6KB1 protein; diphenyleneiodonium inhibits the reaction [Cadmium Chloride results in increased phosphorylation of and results in increased activity of RPS6KB1 protein]; NOTCH1 mutant form inhibits the reaction [Cadmium Chloride results in increased phosphorylation of RPS6KB1 protein]; PTEN inhibits the reaction [Cadmium Chloride results in increased phosphorylation of RPS6KB1 protein]; Sirolimus inhibits the reaction [Cadmium Chloride results in increased phosphorylation of and results in increased activity of RPS6KB1 protein]; U 0126 inhibits the reaction [Cadmium Chloride results in increased phosphorylation of and results in increased activity of RPS6KB1 protein]PMID:21195169 PMID:21984483 PMID:25118938
Rps6kb1multiple interactionsISORps6kb1 (Mus musculus)6480464CTD1,2-bis(2-aminophenoxy)ethane N,N,N',N'-tetraacetic acid acetoxymethyl ester inhibits the reaction [Cadmium Chloride results in increased phosphorylation of RPS6KB1 protein]; 4,6-dimorpholino-N-(4-nitrophenyl)-1,3,5-triazin-2-amine inhibits the reaction [Cadmium Chloride results in decreased phosphorylation of RPS6KB1 protein]; Acetylcysteine inhibits the reaction [Cadmium Chloride results in increased phosphorylation of RPS6KB1 protein]; Egtazic Acid inhibits the reaction [Cadmium Chloride results in increased phosphorylation of RPS6KB1 protein]; Sirolimus inhibits the reaction [Cadmium Chloride results in increased phosphorylation of RPS6KB1 protein]; Trehalose inhibits the reaction [Cholesterol inhibits the reaction [Cadmium Chloride results in increased cleavage of RPS6KB1 protein]]; Trifluoperazine inhibits the reaction [Cadmium Chloride results in increased phosphorylation of RPS6KB1 protein]PMID:21544200 PMID:24299490 PMID:29486218 PMID:35843418
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