Send us a Message
Submit Data |  Help |  Video Tutorials |  News |  Publications |  Download |  REST API |  Citing RGD |  Contact   
Search RGD Grant Resources Citing RGD About Us Contact Us
Genes Variants Community Projects QTLs Strains Markers Genome Information Ontologies Cell Lines References Download Submit Data
OntoMate (Literature Search) JBrowse (Genome Browser) Synteny Browser (VCMap) Variant Visualizer Multi-Ontology Enrichment (MOET) Gene-Ortholog Location Finder (GOLF) InterViewer (Protein-Protein Interactions) PhenoMiner (Quatitative Phenotypes) Gene Annotator OLGA (Gene List Generator) AllianceMine GViewer (Genome Viewer)
Aging & Age-Related Disease Cancer & Neoplastic Disease Cardiovascular Disease Coronavirus Disease Developmental Disease Diabetes Hematologic Disease Immune & Inflammatory Disease Infectious Disease Liver Disease Neurological Disease Obesity & Metabolic Syndrome Renal Disease Respiratory Disease Sensory Organ Disease
Find Models   new Genetic Models Autism Models Rat PhenoMiner (Quantitative Phenotypes) Chinchilla PhenoMiner Expected Ranges (Quantitative Phenotype) PhenoMiner Term Comparison Hybrid Rat Diversity Panel Phenotypes Phenotypes in Other Animal Models Animal Husbandry Strain Medical Records Phylogenetics Strain Availability Calendar Rats 101 Submissions Photo Archive
Pathways
Rat Community Forum Directory of Rat Laboratories Video Tutorials News RGD Publications RGD Presentations Archive Nomenclature Guidelines Resource Links Laboratory Resources Employment Resources

GENE - CHEMICAL INTERACTIONS REPORT

RGD ID: 620682
Species: Rattus norvegicus
RGD Object: Gene
Symbol: Tfam
Name: transcription factor A, mitochondrial
Acc ID: CHEBI:9381
Term: T-2 toxin
Definition: A trichothecene mycotoxin produced by fungi of the genus Fusarium. It is a common contaminant in food and feedstuffs of cereal origin and is known to cause a range of toxic effects in humans and animals.
Chemical ID: MESH:D013605
Note: Use of the qualifier "multiple interactions" designates that the annotated interaction is comprised of a complex set of reactions and/or regulatory events, possibly involving additional chemicals and/or gene products.
Object SymbolQualifierEvidenceWithReferenceSourceNotesOriginal Reference(s)
Tfamincreases expressionEXP 6480464CTDT-2 Toxin results in increased expression of TFAM mRNAPMID:29870751 PMID:36863559
Tfammultiple interactionsEXP 6480464CTDGABPA promotes the reaction [T-2 Toxin results in increased expression of TFAM mRNA]; T-2 Toxin promotes the reaction [GABPA protein binds to TFAM]PMID:36863559
Tfamdecreases expressionISOTFAM (Homo sapiens)6480464CTDT-2 Toxin results in decreased expression of TFAM mRNA; T-2 Toxin results in decreased expression of TFAM proteinPMID:35842139
Tfamdecreases expressionISOTfam (Mus musculus)6480464CTDT-2 Toxin results in decreased expression of TFAM proteinPMID:27363784
Tfammultiple interactionsISOTFAM (Homo sapiens)6480464CTDNFE2L2 protein affects the reaction [T-2 Toxin results in decreased expression of TFAM mRNA]; NFE2L2 protein affects the reaction [T-2 Toxin results in decreased expression of TFAM protein]PMID:35842139
Tfammultiple interactionsISOTfam (Mus musculus)6480464CTD6-hydroxy-2,5,7,8-tetramethylchroman-2-carboxylic acid inhibits the reaction [T-2 Toxin results in decreased expression of TFAM protein]PMID:27363784
Go Back to source page   Continue to Ontology report