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GENE - CHEMICAL INTERACTIONS REPORT

RGD ID: 620679
Species: Rattus norvegicus
RGD Object: Gene
Symbol: Osgin1
Name: oxidative stress induced growth inhibitor 1
Acc ID: CHEBI:29865
Term: benzo[a]pyrene
Definition: An ortho- and peri-fused polycyclic arene consisting of five fused benzene rings.
Chemical ID: MESH:D001564
Note: Use of the qualifier "multiple interactions" designates that the annotated interaction is comprised of a complex set of reactions and/or regulatory events, possibly involving additional chemicals and/or gene products.
Object SymbolQualifierEvidenceWithReferenceSourceNotesOriginal Reference(s)
Osgin1affects methylationISOOSGIN1 (Homo sapiens)6480464CTDBenzo(a)pyrene affects the methylation of OSGIN1 intronPMID:30157460
Osgin1decreases expressionISOOsgin1 (Mus musculus)6480464CTDBenzo(a)pyrene results in decreased expression of OSGIN1 mRNAPMID:19770486
Osgin1decreases methylationISOOSGIN1 (Homo sapiens)6480464CTDBenzo(a)pyrene results in decreased methylation of OSGIN1 promoterPMID:27901495
Osgin1increases expressionISOOsgin1 (Mus musculus)6480464CTDBenzo(a)pyrene results in increased expression of OSGIN1 mRNAPMID:21569818
Osgin1increases expressionISOOSGIN1 (Homo sapiens)6480464CTDBenzo(a)pyrene results in increased expression of OSGIN1 mRNAPMID:15735009 PMID:20106945 PMID:21632981 PMID:22316170 PMID:25690898 PMID:26238291
Osgin1increases methylationISOOSGIN1 (Homo sapiens)6480464CTDBenzo(a)pyrene results in increased methylation of OSGIN1 5' UTRPMID:27901495
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