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GENE - CHEMICAL INTERACTIONS REPORT

RGD ID: 620675
Species: Rattus norvegicus
RGD Object: Gene
Symbol: Rps6ka1
Name: ribosomal protein S6 kinase A1
Acc ID: CHEBI:10022
Term: deoxynivalenol
Definition: A trichothecene mycotoxin produced by Fusarium to which wheat, barley, maize (corn) and their products are susceptible to contamination.
Chemical ID: MESH:C007262
Note: Use of the qualifier "multiple interactions" designates that the annotated interaction is comprised of a complex set of reactions and/or regulatory events, possibly involving additional chemicals and/or gene products.
Object SymbolQualifierEvidenceWithReferenceSourceNotesOriginal Reference(s)
Rps6ka1increases phosphorylationISORps6ka1 (Mus musculus)6480464CTDdeoxynivalenol results in increased phosphorylation of RPS6KA1 proteinPMID:15772366
Rps6ka1multiple interactionsISORps6ka1 (Mus musculus)6480464CTD4-amino-5-(4-methylphenyl)-7-(tert-butyl)pyrazolo(3,4-d)pyrimidine inhibits the reaction [deoxynivalenol results in increased phosphorylation of RPS6KA1 protein]; deoxynivalenol results in increased phosphorylation of and results in increased activity of RPS6KA1 proteinPMID:15772366 PMID:15976193
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