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GENE - CHEMICAL INTERACTIONS REPORT

RGD ID: 620640
Species: Rattus norvegicus
RGD Object: Gene
Symbol: Cyp2d4
Name: cytochrome P450, family 2, subfamily d, polypeptide 4
Acc ID: CHEBI:9944
Term: venlafaxine hydrochloride
Definition: A hydrochloride that has formula C17H27NO2.HCl.
Chemical ID: MESH:D000069470
Note: Use of the qualifier "multiple interactions" designates that the annotated interaction is comprised of a complex set of reactions and/or regulatory events, possibly involving additional chemicals and/or gene products.
QualifierEvidenceWithReferenceSourceNotesOriginal Reference(s)
affects metabolic processingISORGD:7362176480464CTDCYP2D6 gene mutant form affects the metabolism of Venlafaxine Hydrochloride, CYP2D6 gene polymorphism affects the metabolism of Venlafaxine Hydrochloride

PMID:10774634, PMID:16958828, PMID:18214456
affects methylationISORGD:7362176480464CTDCYP2D6 gene polymorphism affects the methylation of Venlafaxine Hydrochloride

PMID:10877013, PMID:10933885
affects response to substanceISORGD:7362176480464CTDCYP2D6 protein affects the susceptibility to Venlafaxine Hydrochloride

PMID:17803873
decreases activityISORGD:7362176480464CTDVenlafaxine Hydrochloride results in decreased activity of CYP2D6 protein

PMID:15632378
decreases methylationISORGD:7362176480464CTDCYP2D6 protein results in decreased methylation of Venlafaxine Hydrochloride

PMID:10877013, PMID:10933885
increases metabolic processingISORGD:7362176480464CTDCYP2D6 protein results in increased metabolism of Venlafaxine Hydrochloride

PMID:10774634, PMID:16044105, PMID:16958828, PMID:18214456
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RGD is funded by grant HL64541 from the National Heart, Lung, and Blood Institute on behalf of the NIH.