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GENE - CHEMICAL INTERACTIONS REPORT

RGD ID: 620640
Species: Rattus norvegicus
RGD Object: Gene
Symbol: Cyp2d4
Name: cytochrome P450, family 2, subfamily d, polypeptide 4
Acc ID: CHEBI:28262
Term: dimethyl sulfoxide
Definition: A 2-carbon sulfoxide in which the sulfur atom has two methyl substituents.
Chemical ID: MESH:D004121
Note: Use of the qualifier "multiple interactions" designates that the annotated interaction is comprised of a complex set of reactions and/or regulatory events, possibly involving additional chemicals and/or gene products.
QualifierEvidenceWithReferenceSourceNotesOriginal Reference(s)
multiple interactionsISORGD:7362176480464CTDDimethyl Sulfoxide inhibits the reaction [POR protein results in decreased expression of CYP2D6 protein], Dimethyl Sulfoxide promotes the reaction [Hemin inhibits the reaction [POR protein results in decreased expression of CYP2D6 protein]], Hemin promotes the reaction [Dimethyl Sulfoxide inhibits the reaction [POR protein results in decreased expression of CYP2D6 protein]]

PMID:11368792
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RGD is funded by grant HL64541 from the National Heart, Lung, and Blood Institute on behalf of the NIH.