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GENE - CHEMICAL INTERACTIONS REPORT

RGD ID: 620640
Species: Rattus norvegicus
RGD Object: Gene
Symbol: Cyp2d4
Name: cytochrome P450, family 2, subfamily d, polypeptide 4
Acc ID: CHEBI:2666
Term: amitriptyline
Definition: An organic tricyclic compound that is 10,11-dihydro-5H-dibenzo[a,d][7]annulene substituted by a 3-(dimethylamino)propylidene group at position 5.
Chemical ID: MESH:D000639
Note: Use of the qualifier "multiple interactions" designates that the annotated interaction is comprised of a complex set of reactions and/or regulatory events, possibly involving additional chemicals and/or gene products.
QualifierEvidenceWithReferenceSourceNotesOriginal Reference(s)
decreases activityISORGD:7362176480464CTDAmitriptyline results in decreased activity of CYP2D6 protein

PMID:18359183
increases metabolic processingISORGD:7362176480464CTDAmitriptyline results in increased metabolism of CYP2D6 protein, CYP2D6 protein results in increased metabolism of Amitriptyline

PMID:16044105, PMID:18359012, PMID:27320963
multiple interactionsISORGD:7362176480464CTD[CYP1A2 protein co-treated with CYP2C9 protein co-treated with CYP3A4 protein co-treated with CYP2D6 protein co-treated with CYP2C19 protein] affects the susceptibility to Amitriptyline

PMID:23397584
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RGD is funded by grant HL64541 from the National Heart, Lung, and Blood Institute on behalf of the NIH.