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GENE - CHEMICAL INTERACTIONS REPORT

RGD ID: 620625
Species: Rattus norvegicus
RGD Object: Gene
Symbol: Dusp4
Name: dual specificity phosphatase 4
Acc ID: CHEBI:16469
Term: 17beta-estradiol
Definition: The 17beta-isomer of estradiol.
Chemical ID: MESH:D004958
Note: Use of the qualifier "multiple interactions" designates that the annotated interaction is comprised of a complex set of reactions and/or regulatory events, possibly involving additional chemicals and/or gene products.
Object SymbolQualifierEvidenceWithReferenceSourceNotesOriginal Reference(s)
Dusp4decreases expressionISODUSP4 (Homo sapiens)6480464CTDEstradiol results in decreased expression of DUSP4 mRNAPMID:16202921
Dusp4increases expressionISODusp4 (Mus musculus)6480464CTDEstradiol results in increased expression of DUSP4 mRNAPMID:19484750
Dusp4increases expressionISODUSP4 (Homo sapiens)6480464CTDEstradiol results in increased expression of DUSP4 mRNAPMID:19153601 PMID:19484750 PMID:19619570 PMID:21185374
Dusp4multiple interactionsISODUSP4 (Homo sapiens)6480464CTD[Estradiol co-treated with Tetrachlorodibenzodioxin] results in increased expression of DUSP4 mRNA; [Estradiol co-treated with TGFB1 protein] results in increased expression of DUSP4 mRNAPMID:19619570 PMID:30165855
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