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GENE - TERM ANNOTATION REPORT

RGD ID: 620600
Species: Rattus norvegicus
RGD Object: Gene
Symbol: Nox4
Name: NADPH oxidase 4
Acc ID: DOID:10763
Term: hypertension
Definition: An artery disease characterized by chronic elevated blood pressure in the arteries. (DO)
Definition Source(s): https://en.wikipedia.org/wiki/Hypertension "DO" "DO", https://www.ncbi.nlm.nih.gov/pubmed/24352797 "DO" "DO"
Note: Use of the qualifier "multiple interactions" designates that the annotated interaction is comprised of a complex set of reactions and/or regulatory events, possibly involving additional chemicals and/or gene products.
Object SymbolQualifierEvidenceWithReferenceSourceNotesOriginal Reference(s)
Nox4 IEP 2324669RGDprotein:increased expression:aorta, vascular associated smooth muscle cell 
Nox4 IMP 11085830RGD  
Nox4 ISONOX4 (Homo sapiens)11554173CTDCTD Direct Evidence: marker/mechanismPMID:27659729 PMID:27847271 PMID:32147540
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