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GENE - CHEMICAL INTERACTIONS REPORT

RGD ID: 620600
Species: Rattus norvegicus
RGD Object: Gene
Symbol: Nox4
Name: NADPH oxidase 4
Acc ID: CHEBI:29073
Term: L-ascorbic acid
Definition: The L-enantiomer of ascorbic acid and conjugate acid of L-ascorbate.
Chemical ID: MESH:D001205
Note: Use of the qualifier "multiple interactions" designates that the annotated interaction is comprised of a complex set of reactions and/or regulatory events, possibly involving additional chemicals and/or gene products.
Object SymbolQualifierEvidenceWithReferenceSourceNotesOriginal Reference(s)
Nox4increases expressionISONox4 (Mus musculus)6480464CTDAscorbic Acid results in increased expression of NOX4 mRNA; Ascorbic Acid results in increased expression of NOX4 proteinPMID:21570463
Nox4multiple interactionsISONOX4 (Homo sapiens)6480464CTDAscorbic Acid inhibits the reaction [Hydrogen Peroxide results in increased expression of NOX4 mRNA]; Ascorbic Acid inhibits the reaction [Hydrogen Peroxide results in increased expression of NOX4 protein]PMID:25305479
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