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GENE - CHEMICAL INTERACTIONS REPORT

RGD ID: 620598
Species: Rattus norvegicus
RGD Object: Gene
Symbol: Nox1
Name: NADPH oxidase 1
Acc ID: CHEBI:28748
Term: doxorubicin
Definition: An anthracycline antibiotic that has formula C27H29NO11.
Chemical ID: MESH:D004317
Note: Use of the qualifier "multiple interactions" designates that the annotated interaction is comprised of a complex set of reactions and/or regulatory events, possibly involving additional chemicals and/or gene products.
Object SymbolQualifierEvidenceWithReferenceSourceNotesOriginal Reference(s)
Nox1increases expressionEXP 6480464CTDDoxorubicin results in increased expression of NOX1 mRNA; Doxorubicin results in increased expression of NOX1 proteinPMID:16213474 PMID:24072175 PMID:24902966 PMID:35843304
Nox1multiple interactionsEXP 6480464CTD2-(2-amino-3-methoxyphenyl)-4H-1-benzopyran-4-one promotes the reaction [Doxorubicin results in increased expression of NOX1 mRNA]; Acetylcysteine inhibits the reaction [Doxorubicin results in increased expression of NOX1 mRNA]; Carvedilol inhibits the reaction [Doxorubicin results in increased expression of NOX1 mRNA]; galangin inhibits the reaction [Doxorubicin results in increased expression of NOX1 protein]; pyrazolanthrone inhibits the reaction [Doxorubicin results in increased expression of NOX1 mRNA]; Quercetin inhibits the reaction [Doxorubicin results in increased expression of NOX1 mRNA]; Razoxane inhibits the reaction [Doxorubicin results in increased expression of NOX1 mRNA]; rhodioloside inhibits the reaction [Doxorubicin results in increased expression of NOX1 mRNA]PMID:16213474 PMID:24072175 PMID:24902966 PMID:35843304
Nox1increases expressionISONox1 (Mus musculus)6480464CTDDoxorubicin results in increased expression of NOX1 mRNA; Doxorubicin results in increased expression of NOX1 proteinPMID:24072175 PMID:31158416
Nox1multiple interactionsISONox1 (Mus musculus)6480464CTDrhodioloside inhibits the reaction [Doxorubicin results in increased expression of NOX1 mRNA]PMID:24072175
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