Gene Chemical Interaction Report - Rat Genome Database

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GENE - CHEMICAL INTERACTIONS REPORT

RGD ID:	620598
Species:	Rattus norvegicus
RGD Object:	Gene
Symbol:	Nox1
Name:	NADPH oxidase 1

Acc ID:	CHEBI:16412
Term:	lipopolysaccharide
Definition:	Liposaccharide natural compounds consisting of a trisaccharide repeating unit (two heptose units and octulosonic acid) with oligosaccharide side chains and 3-hydroxytetradecanoic acid units (they are a major constituent of the cell walls of Gram-negative bacteria).
Chemical ID:	MESH:D008070

Note: Use of the qualifier "multiple interactions" designates that the annotated interaction is comprised of a complex set of reactions and/or regulatory events, possibly involving additional chemicals and/or gene products.

Object Symbol	Qualifier	Evidence	With	Reference	Source	Notes	Original Reference(s)
Nox1	increases expression	EXP		6480464	CTD	Lipopolysaccharides results in increased expression of NOX1 protein	PMID:24973090
Nox1	multiple interactions	EXP		6480464	CTD	Sialic Acids inhibits the reaction [Lipopolysaccharides results in increased expression of NOX1 protein]	PMID:24973090
Nox1	increases activity	ISO	Nox1 (Mus musculus)	6480464	CTD	Lipopolysaccharides results in increased activity of NOX1 protein	PMID:19005069
Nox1	increases expression	ISO	NOX1 (Homo sapiens)	6480464	CTD	Lipopolysaccharides results in increased expression of NOX1 mRNA; Lipopolysaccharides results in increased expression of NOX1 protein	PMID:24835767 PMID:26667767 PMID:35774596
Nox1	increases expression	ISO	Nox1 (Mus musculus)	6480464	CTD	Lipopolysaccharides results in increased expression of NOX1 mRNA; Lipopolysaccharides results in increased expression of NOX1 protein	PMID:19293636 PMID:24835767
Nox1	multiple interactions	ISO	NOX1 (Homo sapiens)	6480464	CTD	alisol B 23-acetate inhibits the reaction [Lipopolysaccharides results in increased expression of NOX1 protein]; CAV1 mutant form promotes the reaction [Lipopolysaccharides results in increased expression of NOX1 mRNA]; NOX1 protein affects the reaction [Lipopolysaccharides affects the localization of NFKB1 protein]; NOX1 protein affects the reaction [Lipopolysaccharides affects the localization of RELA protein]; NOX1 protein affects the reaction [Lipopolysaccharides results in increased phosphorylation of CHUK protein]; Resveratrol inhibits the reaction [Lipopolysaccharides results in increased expression of NOX1 mRNA]	PMID:20715105 PMID:24835767 PMID:26667767 PMID:35774596
Nox1	multiple interactions	ISO	Nox1 (Mus musculus)	6480464	CTD	2-(4-morpholinyl)-8-phenyl-4H-1-benzopyran-4-one inhibits the reaction [Lipopolysaccharides results in increased expression of NOX1 mRNA]; resveratrol inhibits the reaction [Lipopolysaccharides results in increased expression of NOX1 mRNA]	PMID:19293636

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