Send us a Message



Submit Data |  Help |  Video Tutorials |  News |  Publications |  Download |  REST API |  Citing RGD |  Contact   

GENE - CHEMICAL INTERACTIONS REPORT

RGD ID: 620588
Species: Rattus norvegicus
RGD Object: Gene
Symbol: Cd14
Name: CD14 molecule
Acc ID: CHEBI:45863
Term: paclitaxel
Definition: A tetracyclic diterpenoid isolated originally from the bark of the Pacific yew tree, Taxus brevifolia. It is a mitotic inhibitor used in cancer chemotherapy. Note that the use of the former generic name 'taxol' is now limited, as Taxol is a registered trade mark.
Chemical ID: MESH:D017239
Note: Use of the qualifier "multiple interactions" designates that the annotated interaction is comprised of a complex set of reactions and/or regulatory events, possibly involving additional chemicals and/or gene products.
Object SymbolQualifierEvidenceWithReferenceSourceNotesOriginal Reference(s)
Cd14increases expressionEXP 6480464CTDPaclitaxel results in increased expression of CD14 mRNAPMID:18754875
Cd14affects response to substanceISOCd14 (Mus musculus)6480464CTDCD14 protein affects the susceptibility to PaclitaxelPMID:11581577
Cd14multiple interactionsISOCd14 (Mus musculus)6480464CTDCD14 protein affects the reaction [Paclitaxel results in increased expression of IL12A mRNA]; CD14 protein affects the reaction [Paclitaxel results in increased expression of IL12B mRNA]; CD14 protein affects the reaction [Paclitaxel results in increased expression of PTGS2 mRNA]; CD14 protein affects the reaction [Paclitaxel results in increased phosphorylation of MAPK1 protein]; CD14 protein affects the reaction [Paclitaxel results in increased phosphorylation of MAPK3 protein]; CD14 protein affects the reaction [Paclitaxel results in increased phosphorylation of MAPK8 protein]PMID:11123339
Go Back to source page   Continue to Ontology report