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GENE - CHEMICAL INTERACTIONS REPORT

RGD ID: 620562
Species: Rattus norvegicus
RGD Object: Gene
Symbol: Il12a
Name: interleukin 12A
Acc ID: CHEBI:90705
Term: SB 203580
Definition: A member of the class of imidazoles carrying 4-methylsulfinylphenyl, 4-pyridyl and 4-fluorophenyl substituents at positions 2, 4 and 5 respectively. An inhibitor of mitogen-activated protein kinase.
Chemical ID: MESH:C093642
Note: Use of the qualifier "multiple interactions" designates that the annotated interaction is comprised of a complex set of reactions and/or regulatory events, possibly involving additional chemicals and/or gene products.
QualifierEvidenceWithReferenceSourceNotesOriginal Reference(s)
multiple interactionsISORGD:13510476480464CTDSB 203580 inhibits the reaction [[IL12A protein binds to IL12B protein] which results in increased expression of IFNG protein], SB 203580 inhibits the reaction [Drugs, Chinese Herbal results in increased secretion of [IL12A protein binds to IL12B protein]], SB 203580 inhibits the reaction [Polysaccharides results in increased secretion of [IL12A protein binds to IL12B protein]]

PMID:10952721, PMID:15894585
multiple interactionsISORGD:7321406480464CTDSB 203580 inhibits the reaction [Lipopolysaccharides results in increased expression of IL12A mRNA]

PMID:11006016
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RGD is funded by grant HL64541 from the National Heart, Lung, and Blood Institute on behalf of the NIH.