GENE - CHEMICAL INTERACTIONS REPORT
Note: Use of the qualifier "multiple interactions" designates that the annotated interaction
is comprised of a complex set of reactions and/or regulatory events, possibly involving
additional chemicals and/or gene products.
Object Symbol | Qualifier | Evidence | With | Reference | Source | Notes | Original Reference(s) | Il12a | increases expression | ISO | Il12a (Mus musculus) | 6480464 | CTD | Tetrachlorodibenzodioxin results in increased expression of IL12A mRNA | PMID:12167310 | Il12a | multiple interactions | ISO | IL12A (Homo sapiens) | 6480464 | CTD | AHR protein affects the reaction [Tetrachlorodibenzodioxin inhibits the reaction [Lipopolysaccharides results in increased expression of IL12A mRNA]]; CDX2 protein affects the reaction [Tetrachlorodibenzodioxin inhibits the reaction [Lipopolysaccharides results in increased expression of IL12A mRNA]]; Tetrachlorodibenzodioxin inhibits the reaction [CL 075 results in increased expression of IL12A mRNA]; Tetrachlorodibenzodioxin inhibits the reaction [Lipopolysaccharides results in increased expression of IL12A mRNA]; Tetrachlorodibenzodioxin inhibits the reaction [Poly I-C results in increased expression of IL12A mRNA] | PMID:27783115 | Il12a | multiple interactions | ISO | Il12a (Mus musculus) | 6480464 | CTD | Tetrachlorodibenzodioxin inhibits the reaction [[CpG ODN 1826 binds to and results in increased activity of TLR9 protein] results in increased secretion of [IL12A protein binds to IL12B protein]]; Tetrachlorodibenzodioxin inhibits the reaction [[imiquimod binds to and results in increased activity of TLR7 protein] results in increased secretion of [IL12A protein binds to IL12B protein]]; Tetrachlorodibenzodioxin inhibits the reaction [[Lipopolysaccharides binds to and results in increased activity of TLR4 protein] results in increased secretion of [IL12A protein binds to IL12B protein]] | PMID:21097750 | |
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