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GENE - CHEMICAL INTERACTIONS REPORT

RGD ID: 620562
Species: Rattus norvegicus
RGD Object: Gene
Symbol: Il12a
Name: interleukin 12A
Acc ID: CHEBI:28119
Term: 2,3,7,8-tetrachlorodibenzodioxine
Definition: A polychlorinated dibenzodioxine that has formula C12H4Cl4O2.
Chemical ID: MESH:D013749
Note: Use of the qualifier "multiple interactions" designates that the annotated interaction is comprised of a complex set of reactions and/or regulatory events, possibly involving additional chemicals and/or gene products.
Object SymbolQualifierEvidenceWithReferenceSourceNotesOriginal Reference(s)
Il12aincreases expressionISOIl12a (Mus musculus)6480464CTDTetrachlorodibenzodioxin results in increased expression of IL12A mRNAPMID:12167310
Il12amultiple interactionsISOIL12A (Homo sapiens)6480464CTDAHR protein affects the reaction [Tetrachlorodibenzodioxin inhibits the reaction [Lipopolysaccharides results in increased expression of IL12A mRNA]]; CDX2 protein affects the reaction [Tetrachlorodibenzodioxin inhibits the reaction [Lipopolysaccharides results in increased expression of IL12A mRNA]]; Tetrachlorodibenzodioxin inhibits the reaction [CL 075 results in increased expression of IL12A mRNA]; Tetrachlorodibenzodioxin inhibits the reaction [Lipopolysaccharides results in increased expression of IL12A mRNA]; Tetrachlorodibenzodioxin inhibits the reaction [Poly I-C results in increased expression of IL12A mRNA]PMID:27783115
Il12amultiple interactionsISOIl12a (Mus musculus)6480464CTDTetrachlorodibenzodioxin inhibits the reaction [[CpG ODN 1826 binds to and results in increased activity of TLR9 protein] results in increased secretion of [IL12A protein binds to IL12B protein]]; Tetrachlorodibenzodioxin inhibits the reaction [[imiquimod binds to and results in increased activity of TLR7 protein] results in increased secretion of [IL12A protein binds to IL12B protein]]; Tetrachlorodibenzodioxin inhibits the reaction [[Lipopolysaccharides binds to and results in increased activity of TLR4 protein] results in increased secretion of [IL12A protein binds to IL12B protein]]PMID:21097750
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