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GENE - CHEMICAL INTERACTIONS REPORT

RGD ID: 620562
Species: Rattus norvegicus
RGD Object: Gene
Symbol: Il12a
Name: interleukin 12A
Acc ID: CHEBI:18295
Term: histamine
Definition: A member of the class of imidazoles that is 1H-imidazole substituted at position C-4 by a 2-aminoethyl group.
Chemical ID: MESH:D006632
Note: Use of the qualifier "multiple interactions" designates that the annotated interaction is comprised of a complex set of reactions and/or regulatory events, possibly involving additional chemicals and/or gene products.
QualifierEvidenceWithReferenceSourceNotesOriginal Reference(s)
decreases expressionISORGD:13510476480464CTDHistamine results in decreased expression of IL12A mRNA, Histamine results in decreased expression of IL12A protein

PMID:9819373
increases expressionISORGD:13510476480464CTDHistamine results in increased expression of IL12A protein

PMID:15843518
multiple interactionsISORGD:13510476480464CTD[Histamine results in increased activity of HRH2 protein] which results in decreased expression of IL12A protein, [Histamine results in increased activity of HRH4 protein] which results in decreased expression of IL12A protein, [IL12A protein binds to IL12B protein] inhibits the reaction [Histamine inhibits the reaction [IL18 protein results in decreased expression of IL10 protein]], [IL12A protein binds to IL12B protein] inhibits the reaction [Histamine inhibits the reaction [IL18 protein results in increased expression of IFNG protein]], Cyclic AMP promotes the reaction [[Histamine results in increased activity of HRH2 protein] which results in decreased expression of IL12A protein], Famotidine inhibits the reaction [Histamine inhibits the reaction [IL18 protein results in increased expression of [IL12A protein binds to IL12B protein]]], Histamine inhibits the reaction [IL18 protein results in increased expression of [IL12A protein binds to IL12B protein]], HRH2 protein affects the reaction [Histamine inhibits the reaction [IL18 protein results in increased expression of [IL12A protein binds to IL12B protein]]], HRH2 protein promotes the reaction [Histamine results in decreased expression of IL12A protein], Ranitidine inhibits the reaction [Histamine inhibits the reaction [IL18 protein results in increased expression of [IL12A protein binds to IL12B protein]]], Ranitidine inhibits the reaction [Histamine results in decreased expression of IL12A protein], U 0126 inhibits the reaction [[Histamine results in increased activity of HRH4 protein] which results in decreased expression of IL12A protein]

PMID:11752121, PMID:12364868, PMID:15843518, PMID:9819373
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RGD is funded by grant HL64541 from the National Heart, Lung, and Blood Institute on behalf of the NIH.