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GENE - CHEMICAL INTERACTIONS REPORT

RGD ID: 620562
Species: Rattus norvegicus
RGD Object: Gene
Symbol: Il12a
Name: interleukin 12A
Acc ID: CHEBI:17026
Term: progesterone
Definition: A C21-steroid hormone in which a pregnane skeleton carries oxo substituents at positions 3 and 20 and is unsaturated at C(4)-C(5). As a hormone, it is involved in the female menstrual cycle, pregnancy and embryogenesis of humans and other species.
Chemical ID: MESH:D011374
Note: Use of the qualifier "multiple interactions" designates that the annotated interaction is comprised of a complex set of reactions and/or regulatory events, possibly involving additional chemicals and/or gene products.
QualifierEvidenceWithReferenceSourceNotesOriginal Reference(s)
multiple interactionsISORGD:13510476480464CTD[Progesterone co-treated with Estradiol] inhibits the reaction [Vaccines, Virus-Like Particle results in increased expression of [IL12A protein binds to IL12B protein]], Progesterone inhibits the reaction [Vaccines, Virus-Like Particle results in increased expression of [IL12A protein binds to IL12B protein]], Progesterone results in increased expression of [IL12A protein binds to IL12B protein]

PMID:20130130
multiple interactionsISORGD:7321406480464CTD[Estradiol co-treated with Progesterone] results in decreased expression of IL12A mRNA

PMID:19693291
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RGD is funded by grant HL64541 from the National Heart, Lung, and Blood Institute on behalf of the NIH.