GENE - CHEMICAL INTERACTIONS REPORT
Note: Use of the qualifier "multiple interactions" designates that the annotated interaction
is comprised of a complex set of reactions and/or regulatory events, possibly involving
additional chemicals and/or gene products.
Object Symbol | Qualifier | Evidence | With | Reference | Source | Notes | Original Reference(s) | Mcl1 | decreases response to substance | ISO | Mcl1 (Mus musculus) | 6480464 | CTD | MCL1 protein results in decreased susceptibility to vorinostat | PMID:19060243 | Mcl1 | multiple interactions | ISO | MCL1 (Homo sapiens) | 6480464 | CTD | [(+)-JQ1 compound co-treated with vorinostat] results in decreased expression of MCL1 protein; [[Bortezomib co-treated with vorinostat] results in increased abundance of Reactive Oxygen Species] which results in decreased expression of MCL1 protein; [Bortezomib co-treated with vorinostat] results in decreased expression of MCL1 protein; Acetylcysteine inhibits the reaction [[Bortezomib co-treated with vorinostat] results in decreased expression of MCL1 protein]; Boc-D-FMK inhibits the reaction [[Bortezomib co-treated with vorinostat] results in decreased expression of MCL1 protein] | PMID:15173093 PMID:26390243 | | ||||||||||||||||||||||
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