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GENE - CHEMICAL INTERACTIONS REPORT

RGD ID: 620525
Species: Rattus norvegicus
RGD Object: Gene
Symbol: Mcl1
Name: MCL1 apoptosis regulator, BCL2 family member
Acc ID: CHEBI:16243
Term: quercetin
Definition: A pentahydroxyflavone having the five hydroxy groups placed at the 3-, 3'-, 4'-, 5- and 7-positions. It is one of the most abundant flavonoids in edible vegetables, fruit and wine.
Chemical ID: MESH:D011794
Note: Use of the qualifier "multiple interactions" designates that the annotated interaction is comprised of a complex set of reactions and/or regulatory events, possibly involving additional chemicals and/or gene products.
Object SymbolQualifierEvidenceWithReferenceSourceNotesOriginal Reference(s)
Mcl1decreases expressionISOMCL1 (Homo sapiens)6480464CTDQuercetin results in decreased expression of MCL1 mRNA; Quercetin results in decreased expression of MCL1 proteinPMID:12874837 PMID:20596804 PMID:21138867 PMID:21750559 PMID:23353698 PMID:25084985 PMID:25293876 PMID:30152185
Mcl1decreases expressionISOMcl1 (Mus musculus)6480464CTDQuercetin results in decreased expression of MCL1 proteinPMID:24275163
Mcl1decreases response to substanceISOMCL1 (Homo sapiens)6480464CTDMCL1 protein results in decreased susceptibility to QuercetinPMID:21138867
Mcl1increases expressionISOMCL1 (Homo sapiens)6480464CTDQuercetin results in increased expression of MCL1 mRNAPMID:21933852 PMID:36982678
Mcl1multiple interactionsISOMCL1 (Homo sapiens)6480464CTDbenzyloxycarbonylleucyl-leucyl-leucine aldehyde inhibits the reaction [Quercetin results in decreased expression of MCL1 protein]; MCL1 protein inhibits the reaction [Quercetin results in increased activity of CASP3 protein]; MCL1 protein inhibits the reaction [Quercetin results in increased activity of CASP7 protein]; MCL1 protein inhibits the reaction [Quercetin results in increased activity of CASP9 protein]; MCL1 protein inhibits the reaction [Quercetin results in increased localization of and results in increased activity of BAX protein]; Quercetin inhibits the reaction [TNFSF10 protein results in increased expression of MCL1 protein]; Quercetin promotes the reaction [Dactinomycin results in decreased expression of MCL1 mRNA]; Quercetin results in decreased expression of and results in decreased stability of MCL1 mRNA; Quercetin results in decreased expression of and results in increased ubiquitination of MCL1 proteinPMID:21138867 PMID:21750559 PMID:21933852 PMID:23353698
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