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GENE - CHEMICAL INTERACTIONS REPORT

RGD ID: 620505
Species: Rattus norvegicus
RGD Object: Gene
Symbol: Crh
Name: corticotropin releasing hormone
Acc ID: CHEBI:31429
Term: colforsin daropate hydrochloride
Definition: The hydrochloride salt of colforsin daropate. It is a drug used for the treatment of acute heart failure. It directly stimulates adenylate cyclase and produces positive inotropic and vasodilator effects accompanied by the increase in cellular cAMP.
Chemical ID: MESH:D005576
Note: Use of the qualifier "multiple interactions" designates that the annotated interaction is comprised of a complex set of reactions and/or regulatory events, possibly involving additional chemicals and/or gene products.
Object SymbolQualifierEvidenceWithReferenceSourceNotesOriginal Reference(s)
Crhmultiple interactionsEXP 6480464CTDCRH protein inhibits the reaction [[Colforsin co-treated with CGB3 protein] results in increased chemical synthesis of Cyclic AMP]; CRH protein inhibits the reaction [[Colforsin co-treated with CGB3 protein] results in increased chemical synthesis of Testosterone]; CRH protein inhibits the reaction [Colforsin results in increased chemical synthesis of Cyclic AMP]; CRH protein inhibits the reaction [Colforsin results in increased chemical synthesis of Testosterone]PMID:2153673
Crhincreases secretionISOCRH (Homo sapiens)6480464CTDColforsin results in increased secretion of CRH proteinPMID:33144174
Crhmultiple interactionsISOCRH (Homo sapiens)6480464CTD[perfluorooctane sulfonic acid co-treated with Colforsin] results in increased expression of CRH mRNAPMID:33144174
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