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GENE - TERM ANNOTATION REPORT

RGD ID: 62048
Species: Rattus norvegicus
RGD Object: Gene
Symbol: Top2a
Name: DNA topoisomerase II alpha
Acc ID: GO:0005730
Term: nucleolus
Definition: A small, dense body one or more of which are present in the nucleus of eukaryotic cells. It is rich in RNA and protein, is not bounded by a limiting membrane, and is not seen during mitosis. Its prime function is the transcription of the nucleolar DNA into 45S ribosomal-precursor RNA, the processing of this RNA into 5.8S, 18S, and 28S components of ribosomal RNA, and the association of these components with 5S RNA and proteins synthesized outside the nucleolus. This association results in the formation of ribonucleoprotein precursors; these pass into the cytoplasm and mature into the 40S and 60S subunits of the ribosome.
Definition Source(s): ISBN:0198506732
Note: Use of the qualifier "multiple interactions" designates that the annotated interaction is comprised of a complex set of reactions and/or regulatory events, possibly involving additional chemicals and/or gene products.
Object SymbolQualifierEvidenceWithReferenceSourceNotesOriginal Reference(s)
Top2aNOT|located_inISOTOP2A (Homo sapiens)1624291RGD PMID:9049244

PMID:9049244
Top2alocated_inISOTOP2A (Homo sapiens)1624291RGD PMID:17567603 PMID:8299728 PMID:9155056

PMID:17567603 PMID:8299728 PMID:9155056
Top2alocated_inISOTOP2A (Homo sapiens) or UniProtKB:P11388-11624291RGD GO_REF:0000052
Top2alocated_inISOTop2a (Mus musculus)1624291RGD PMID:11835579

PMID:11835579
Top2alocated_inIEAUniProtKB-SubCell:SL-01881600115UniProtGO_REF:0000044

GO_REF:0000044
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