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GENE - CHEMICAL INTERACTIONS REPORT

RGD ID: 620465
Species: Rattus norvegicus
RGD Object: Gene
Symbol: Cxcr4
Name: C-X-C motif chemokine receptor 4
Acc ID: CHEBI:4027
Term: cyclophosphamide
Definition: A phosphorodiamide that is 1,3,2-oxazaphosphinan-2-amine 2-oxide substituted by two 2-chloroethyl groups at the amino nitrogen atom.
Chemical ID: MESH:D003520
Note: Use of the qualifier "multiple interactions" designates that the annotated interaction is comprised of a complex set of reactions and/or regulatory events, possibly involving additional chemicals and/or gene products.
Object SymbolQualifierEvidenceWithReferenceSourceNotesOriginal Reference(s)
Cxcr4affects localizationEXP 6480464CTDCyclophosphamide affects the localization of CXCR4 proteinPMID:19066630
Cxcr4increases expressionEXP 6480464CTDCyclophosphamide results in increased expression of CXCR4 mRNA; Cyclophosphamide results in increased expression of CXCR4 proteinPMID:19066630 PMID:20032115
Cxcr4multiple interactionsEXP 6480464CTDCyclophosphamide promotes the reaction [MIF protein binds to CXCR4 protein]PMID:19066630
Cxcr4decreases expressionISOCxcr4 (Mus musculus)6480464CTDCyclophosphamide results in decreased expression of CXCR4 mRNAPMID:21041162
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