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GENE - CHEMICAL INTERACTIONS REPORT

RGD ID: 620436
Species: Rattus norvegicus
RGD Object: Gene
Symbol: Cga
Name: glycoprotein hormones, alpha polypeptide
Acc ID: CHEBI:17347
Term: testosterone
Definition: An androstanoid having 17beta-hydroxy and 3-oxo groups, together with unsaturation at C-4-C-5..
Chemical ID: MESH:D013739
Note: Use of the qualifier "multiple interactions" designates that the annotated interaction is comprised of a complex set of reactions and/or regulatory events, possibly involving additional chemicals and/or gene products.
QualifierEvidenceWithReferenceSourceNotesOriginal Reference(s)
increases abundanceEXP 6480464CTDCGA protein results in increased abundance of Testosterone

PMID:21458522
increases secretionEXP 6480464CTDCGA protein results in increased secretion of Testosterone

PMID:19883722, PMID:19921479
multiple interactionsEXP 6480464CTDCGA protein promotes the reaction [CRH protein results in increased secretion of Testosterone], nonylphenol inhibits the reaction [CGA protein results in increased secretion of Testosterone], Taurine affects the reaction [CGA protein results in increased secretion of Testosterone]

PMID:19883722, PMID:19921479, PMID:23133512
increases abundanceISORGD:13485906480464CTDCGA results in increased abundance of Testosterone

PMID:21737371
increases secretionISORGD:13485906480464CTDCGA protein results in increased secretion of Testosterone

PMID:19228890, PMID:19603415, PMID:21642635, PMID:23133512
multiple interactionsISORGD:13485906480464CTD2-hydroxy-3, 5, 3', 5'-tetramethoxystilbene inhibits the reaction [CGA protein results in increased secretion of Testosterone], 3, 4', 5-trimethoxystilbene inhibits the reaction [CGA protein results in increased secretion of Testosterone], [CGA protein co-treated with FSHB protein] affects the abundance of Testosterone, Benzo(a)pyrene inhibits the reaction [CGA results in increased abundance of Testosterone], Flame Retardants promotes the reaction [CGA protein results in increased secretion of Testosterone], FSHB protein promotes the reaction [CGA protein results in increased secretion of Testosterone], resveratrol analog inhibits the reaction [CGA protein results in increased secretion of Testosterone], resveratrol inhibits the reaction [CGA protein results in increased secretion of Testosterone]

PMID:19228890, PMID:19603415, PMID:21642635, PMID:21737371, PMID:22451503
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RGD is funded by grant HL64541 from the National Heart, Lung, and Blood Institute on behalf of the NIH.